Luteolin Extract Manufacturer

Luteolin is a natural flavonoid compound widely present in nature, belonging chemically to the flavonoid class. It is distributed in various vegetables, fruits, herbs, and medicinal plants, and the plant source of this product's specification of luteolin is specifically the dried flower buds of the leguminous plant Sophora Japonica L., which is the traditional Chinese medicinal herb "Sophora japonica".
This product is high-purity (≥ 98%) luteolin powder, refined from Sophora japonica using modern extraction and purification processes. The product is positioned as the core functional ingredient of high-end dietary supplements, aiming to meet the growing demand of consumers for enhancing immunity, anti-aging, maintaining neurological health, and cardiovascular health. Its extensive and scientifically validated biological activity makes it a highly valuable "star ingredient" in formula development.[1-2]

3.1 Raw material pretreatment: Select high-quality and pollution-free Sophora Japonica L. as the raw material, clean, dry, and crush it.
3.2 Solvent extraction: Food-grade solvents (such as ethanol-water solution) are used for extraction to ensure that luteolin and its glycoside derivatives are fully dissolved, forming an extraction solution.
3.3 Filtration and concentration: The extract is filtered through a plate or centrifuge to remove plant residues and obtain a clear extract. Subsequently, the majority of the solvent was recovered at a lower temperature using a vacuum concentration device, and the liquid was concentrated to obtain the extract.
3.5 Purification and refinement: This is the core step in obtaining high-purity products.
3.6 Crystallization/Recrystallization: By changing the polarity of the eluent, the enriched flavonoid components are eluted. Adjust the pH, temperature, and concentration of the eluent to allow for the crystallization and precipitation of luteolin.
3.7 Drying and crushing: The obtained crystals are dried at low temperatures in a vacuum drying oven to remove residual solvents and moisture. After drying, the product is crushed and sieved to ensure uniform particle size and good flowability.

4.1 Powerful antioxidant activity

As an excellent antioxidant, the mechanism of action of luteolin is mainly reflected in two aspects:

• Direct elimination of free radicals: The phenolic hydroxyl groups in its molecular structure can provide hydrogen atoms, directly neutralizing harmful free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the body, thereby reducing oxidative stress damage to cells, proteins, and DNA.[1-2]
• Enhancing endogenous antioxidant system: luteolin can activate the Nrf2 ARE signaling pathway in cells, upregulate the expression of endogenous antioxidant enzymes such as glutathione peroxidase (GSH Px) and superoxide dismutase (SOD), and fundamentally enhance the body's antioxidant defense ability.

4.2 Significant anti-inflammatory effects

Chronic inflammation is considered a common pathological basis for various modern chronic diseases, such as cardiovascular disease and neurodegenerative diseases. Luteolin exerts anti-inflammatory effects through multiple pathways:
Inhibition of pro-inflammatory cytokines: It can effectively inhibit the activation of key inflammatory signaling pathways such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK), thereby reducing the production and release of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 β (IL-1β).[2]
Regulating inflammatory enzyme activity: It can inhibit the expression and activity of enzymes closely related to inflammatory response, such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).

4.3 Neuroprotective Potential

Luteolin can cross the blood-brain barrier and exert a protective effect on the central nervous system, which shows great potential in improving cognition and delaying neurodegenerative diseases.[1-2]

• Reduce neuroinflammation: By inhibiting the excessive activation of microglia and astrocytes in the brain, reduce neuroinflammatory responses.
• Antioxidant damage: protects neurons from oxidative stress damage.
• Regulating neurotransmitters: has potential regulatory effects on maintaining the balance of neurotransmitters in the brain.

 

Benefits

 

Powerful antioxidant activity

Significant anti-inflammatory effects

Neuroprotective Potential

According to a market analysis in August 2025, dietary supplements are the largest application area in the combined market of luteolin and quercetin, accounting for approximately 42% of the market share.[4] This fully demonstrates its core position in the health consumer goods market.

• Single ingredient product: Capsules or tablets containing high-purity luteolin
• Compound formula products: can synergistically enhance with other antioxidants such as vitamin C, quercetin, resveratrol, curcumin, and fish oil.

Research has shown that the relatively low bioavailability of luteolin is a major challenge for its application.[3] Therefore, new formulations developed by advanced delivery technologies such as liposomes, nano lotion, and solid dispersions can significantly improve their absorption and biological activity, which is an important direction for future product development.

Other application areas

• Functional foods and beverages: As natural antioxidants and anti-inflammatory ingredients, they can be added to energy bars, health drinks, yogurt, and other products.
• Cosmetics and skincare products: Utilizing their powerful antioxidant and anti-inflammatory properties, they can be used to develop anti-aging, anti-sensitivity, and post-sun repair skincare products.

6.1 High concentration: Our Luteolin Extract offers one of the highest concentrations of Luteolin available in the market. With such a high concentration of the compound, the product offers an efficient way for people to consume Luteolin and benefit from its properties.

6.2 Purity: The purity and quality of Luteolin are essential in ensuring that consumers receive the maximum benefits of Luteolin. Our Luteolin Extract is made with high-quality ingredients, free from any harmful chemicals or additives.

6.3 Versatility: Luteolin can be used in a variety of applications, including dietary supplements, skincare products, and food products. This versatility makes it an attractive option for businesses looking to incorporate Luteolin into products.

Security statement：

Our company guarantees that the goods sent are safe, non-flammable, and non-explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company. 

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Reference
[1]Luteolin: A versatile flavonoid for anti-inflammatory, anti-cancer, and neuroprotective therapies. Summayya Maryam et al. [2024-11-10]
[2]Nobiletin and Eriodictyol Suppress Release of IL-1β, CXCL8, IL-6, and MMP-9 from LPS, SARS-CoV-2 Spike Protein, and Ochratoxin A-Stimulated Human Microglia. Tsilioni et al. [2025-01-01]
[3]Luteolin: A Comprehensive Review of its Chemical Properties, Biological Activities, and Therapeutic Potential. Ibrahim Mohammed et al. [2025-02-12]
[4]Luteolin Vs Quercetin: Antioxidant Activity Comparison. Patsnap Eureka. [2025-08-28]