Ambroxide 99% Powder

Ambroxide powder is synthesized from Sclareolide, which is a white crystal powder, with a melting point of 74-76°C, a specific optical rotation of -21°~-24°, Ambroxide powder is a synthetic fragrance with a special aroma of natural ambergris, and it is one of the four famous and precious animal fragrances in the world- - A natural alternative to ambergris, one of the most critical trace ingredients of natural ambergris tinctures. Natural ambergris is a precious animal spice. It is a stone in the stomach of a sperm whale. It is vomited or excreted by the whale on the sea surface, and it emits a special fragrance in the air for a long time.

Molecular formula: C16H28O

Molecular weight: 236.39

EINECS/ELINCS Registration Number: 229-861-2

Structural formula:

The production of ambroxide is a classic "nature-to-lab" process, combining the natural origin of plant extraction with the efficiency and consistency of chemical synthesis. The entire process can be divided into two main steps:

Step 1: Extraction and Purification of Sclareol

Clary Sage is commercially grown in multiple regions around the world, such as France, Russia, Bulgaria, and the United States. During the flowering period of plants, their aboveground parts (flowers, stems, leaves) are harvested because the content of sclareol is highest at this time. The raw materials are typically dried after harvesting to lower moisture levels, thereby improving storage stability and preparing them for solvent extraction. After filtering and vacuum distillation to remove the solvent, a semi-solid substance is obtained from the extraction solution. This extract contains sclareol as well as impurities such as wax and pigments. Subsequently, high-purity sclareol crystals were isolated and purified from the extract using purification techniques, including recrystallization.

Step 2: Semi-Synthesis from Sclareol to Ambroxide

This is the core chemical step of converting natural molecules into target spice molecules. The industrial sector has developed multiple mature synthetic routes, among which the most classic and widely used routes include the following key transformations:

• Oxidative Degradation: High purity Sclareol is subjected to side chain oxidative cleavage using oxidants such as potassium permanganate and chromic acid, resulting in the formation of the key intermediate - Sclareolide. This step is a critical part of the entire synthesis process, significantly influencing both yield and cost.
• Reduction reaction: The carbonyl group of Sclareolide is reduced by a strong reducing agent (such as lithium aluminum hydride or sodium borohydride) to produce a diol intermediate, Ambrodiol.
• Dehydration and Cycling: Finally, under the action of an acidic catalyst, the diol intermediate undergoes intramolecular dehydration, forming a five-membered ether ring structure, and ultimately obtaining ambroxide.
• Final Purification: The crude ambroxide requires further purification through distillation or recrystallization to eliminate by-products and unreacted starting materials, resulting in a commercial-grade product with a purity exceeding 99%._[1]

The reason ambroxide is hailed as "white gold" in the fragrance world stems from its irreplaceable olfactory efficacy and its unique role in perfume formulations.

5.1 Core Efficacy: Unique Olfactory Profile

The scent of ambroxide is extremely complex and layered. It is not a single note but a multifaceted combination, primarily including:

①Warm Ambergris: This is its core characteristic, mimicking the warm, slightly animalic, and salty marine aroma of natural ambergris, lending a sophisticated, skin-like sensuality to perfumes.
②Dry Woody Notes: It possesses clear notes of cedar and dry woods, providing a solid structure and depth to the fragrance composition.
③Elegant Muskiness: In the dry-down, it exudes a clean, soft, powdery feel similar to white musk, making the scent more rounded and long-lasting.

5.2 Mechanism of Action: Excellent Fixation and Enhancement

• High-Performance Fixative: Ambroxide has a relatively large molecular weight and an extremely low evaporation rate. In a perfume formula, it acts like an "anchor," effectively "holding onto" more volatile top notes (like citrus) and middle notes (like florals), slowing their evaporation. This significantly extends the perfume's longevity on the skin and enhances its sillage (projection).
• Aroma Enhancer and Harmonizer: Ambroxide has an excellent "brightening" and "blending" effect. It can amplify the positive attributes of other fragrance ingredients in a formula, making florals more vibrant, fruits fresher, and woods deeper. At the same time, it seamlessly connects different notes, making the entire fragrance structure more complete, harmonious, and rounded, creating an indescribable sense of "luxury."

Ambroxide powder can be used in the essence of high-end perfume and cosmetics. It is not irritating to the human body. This product is well-suited for use in skin, hair, and fabric fragrances, such as those in soap, talcum powder, and perfume, and also acts as an effective fixative in creams and shampoos.

Application of Ambergris Flavor Raw Materials in Cigarettes Labatin is the key aroma-inducing ingredient of oriental cigarettes, and Ambroxide is one of the spices with a particularly prominent effect, making an important contribution to the smoke of mixed cigarettes. Ambroxide powder is also widely used in flue-cured tobacco and perfume industries. Ambroxide is used as a flavoring agent in the cigarette industry. It complements the natural flavor of tobacco and neutralizes undesirable odors. Even when used sparingly, it improves the overall taste quality. It is especially suitable for flavoring mixed cigarettes and enhancing oriental flavor.

Ambroxide has undergone extensive toxicological studies and safety assessments, and is generally considered safe at normal concentrations for use in cosmetics and personal care products. Its product has high purity, does not contain animal-derived ingredients, and according to EU cosmetics regulations, it does not belong to one of the 26 known spice allergens that require labeling._[1] This indicates a low risk of sensitization.

7.1 International Fragrance Association (IFRA):

Ambroxide is regulated in the IFRA standard. According to IFRA standards (such as the 51st Amendment), the maximum allowable concentration for use varies among different product categories. For example, in some product categories, such as lip products, their use may be strictly restricted or prohibited. In other product categories (such as body milk, perfume), there is a higher level of permissible use.

7.2 European Union

In the EU market, cosmetics are strictly regulated by the EU Cosmetics Regulation (EC) No 1223/2009._[2] Ambroxide is used as a spice ingredient under this regulatory framework. As mentioned earlier, it does not belong to the legal allergens that must be labeled in the ingredient list. Annex III of the regulation lists restricted substances and their maximum allowable concentrations, but the current search results do not provide a specific entry for ambroxide in that annex._[3]

7.3 United States

In the United States, cosmetics are regulated by the Food and Drug Administration (FDA). The FDA adopts "labeling" management for spice ingredients, requiring them to be uniformly labeled as "Fragrance" or "Parfum" in the ingredient list. Although the FDA does not pre-approve every spice ingredient, manufacturers have a responsibility to ensure the safety of their products.

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