Hawthorn Leaf Extract

Hawthorn Leaf Extract is a natural botanical extract derived from the foliage of Crataegus pinnatifida. Hawthorn Leaf Extract is recognised for its notable efficacy in enhancing cardiac function, providing antioxidant benefits, and reducing blood lipid levels. Rich in bioactive compounds such as flavonoids, phenolic acids, and polysaccharides, hawthorn leaves offer unique contributions to diverse health formulations, particularly for cardiovascular health and circulatory system support.

APPCHEM's Hawthorn Leaf Extract focuses on isolating and concentrating key bioactive compounds from hawthorn leaves. Through advanced solvent extraction, multi-stage separation, and purification processes, it ensures maximum purity, stability, and potency in every batch. Our standardised extraction process precisely controls the flavonoid content in the hawthorn leaf extract, maximising its efficacy in dietary supplements while ensuring batch consistency and high quality.

Hawthorn Leaf Extract is typically supplied in powder or granule form, offering excellent formulation compatibility and processing adaptability. It is suitable for various dietary supplement dosage forms, including tablets, capsules, and granules. In practical applications, Hawthorn Leaf Extract is frequently utilised in formulations supporting cardiovascular health, improving blood circulation, lowering cholesterol, and providing antioxidant protection. It may also be synergistically combined with other botanical extracts-such as jujube, grape seed extract, and quercetin-to enhance cardiac health and vascular protective effects.

XI'AN APP-CHEM BIO (TECH) CO., LTD. (APPCHEM) provides Hawthorn Leaf Extract utilising a mature, reproducible industrial plant extraction process, comprising the following principal steps:

1. Washing
2. Filtering
3. Removing impurities
4. Drying: to prevent high-temperature damage to thermosensitive active ingredients, especially volatile oils.
5. Crushing: (such as 80 mesh) to increase the contact area with the solvent and improve extraction efficiency.
6. Extraction
7. Solid-liquid separation
8. Purification
9. Concentrate
10. Drying
11. Smashing
12. Packaging
13. Finished product

The multifaceted health benefits of hawthorn leaf extract stem from the synergistic action of its active constituents, whose mechanisms of action have been elucidated through extensive in vitro, animal, and partial clinical studies.

• Dilating Coronary Arteries and Enhancing Myocardial Blood Supply

Hawthorn leaf extract effectively dilates blood vessels, particularly the coronary arteries. This mechanism may relate to its promotion of nitric oxide (NO) release from vascular endothelial cells, as NO is a potent vasodilator. Beyond this vasodilatory effect, the extract exhibits mild diuretic properties, aiding in the excretion of excess sodium and water from the body. This reduces blood volume, thereby assisting in blood pressure reduction. This multi-targeted, gentle hypotensive mechanism renders it an ideal natural supplement ingredient for managing mild hypertension.

• Optimising Blood Lipid Levels

Hawthorn leaf extract regulates lipid metabolism. Its active components inhibit cholesterol synthesis in the liver while promoting its conversion into bile acids, thereby accelerating its excretion from the body. Concurrently, it reduces serum levels of low-density lipoprotein cholesterol (LDL-C, "bad cholesterol") and triglycerides (TG), while potentially elevating high-density lipoprotein cholesterol (HDL-C, "good cholesterol").

• Anti-atherosclerotic Effects

Hawthorn leaf extract's potent antioxidant capacity effectively inhibits oxidative modification of LDL-C, preventing its uptake by macrophages to form foam cells. This delays or halts the formation and progression of atherosclerotic plaques. Furthermore, its anti-inflammatory action mitigates vascular wall inflammation, providing additional protection to the vascular endothelium and maintaining arterial elasticity.

• Potent Antioxidant and Anti-inflammatory Activity

The flavonoids and phenolic acids abundant in hawthorn leaf extract constitute potent natural antioxidants. These molecules contain multiple phenolic hydroxyl groups that directly scavenge various free radicals-including reactive oxygen species (ROS) and reactive nitrogen species (RNS)-within the body. This interrupts free radical chain reactions, safeguarding cell membranes, proteins, and DNA from oxidative damage.

• Inhibition of Inflammatory Responses

Chronic inflammation constitutes a common pathological basis for numerous cardiovascular and metabolic disorders. Hawthorn leaf extract inhibits the production and release of multiple pro-inflammatory mediators. For instance, it suppresses the activity of cyclooxygenase-2 (COX-2) and lipoxygenase (LOX), thereby reducing the synthesis of prostaglandins and leukotrienes. Concurrently, it downregulates the expression of inflammatory cytokines such as tumour necrosis factor-α (TNF-α) and interleukins, exerting significant anti-inflammatory effects.

With its exceptional efficacy and favourable safety profile, our hawthorn leaf extract is the ideal choice for developing next-generation cardiovascular health products. Its diverse application areas and product formats cater to varied market demands.

Recommended Product Forms

1. Hard Capsules & Tablets: The most classic and widely accepted dosage form. Our extract powder features uniform particle size (80-100 mesh), excellent flowability, and ease of tableting and capsule filling, enabling precise dose control.
2. Powders & Instant Drinks: Suitable for products intended for direct consumption as a drink or for incorporation into foods. Our high-specification extracts (e.g., 80% total flavonoids) ensure effective dosages with minimal additions and negligible flavour impact.
3. Liquid Formulations: Including oral liquids, drops, syrups, and functional beverages. Benefiting from excellent water solubility, our extracts dissolve readily to form clear, stable solutions.
4. Softgels: Enable the combination of hawthorn leaf extract with fat-soluble nutrients like fish oil or flaxseed oil, utilising oily carriers to enhance absorption and develop synergistic compound products.

The product is mainly in the form of standardised plant extract powder and supports customisation of content, making it easy for OEM/ODM customers to design formulas.
 

Security statement：

Our company guarantees that the goods sent are safe, non-flammable, and non-explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company.

Hot Tags: Hawthorn Leaf Extract manufacturers, suppliers, factory, wholesale, best, price, buy, for sale, bulk.

Long-term cooperative logistics companies include international logistics companies such as DHL, FedEx, UPS, etc.

The regular bulk packaging of the product is a 25kg plastic bag and a cardboard drum. The sample is packaged in an inner aluminium foil bag and an outer plastic bag, supporting customised packaging solutions.

XI'AN APP-CHEM BIO (TECH) CO., LTD. (APPCHEM) regularly participates in international raw material exhibitions such as CPHI, SSW, and In Cosmetics Asia, and establishes long-term cooperative relationships with global customers.

Q1. How is the purity of this product verified?
A1: We employ authoritative analytical methods such as High Performance Liquid Chromatography (HPLC) and Ultraviolet Spectroscopy (UV) to ensure the content.

Q2. What is the minimum order quantity for Hawthorn Leaf Extract?
A2: Our minimum order quantity (MOQ) varies by product and specific requirements, and is typically negotiable. Please contact us for detailed information.

Q3. What is the delivery timeframe for the product?
A3: Delivery times depend on order volume and product type. Generally, we arrange production and dispatch promptly upon order confirmation.

Q4. Does APPCHEM offer customisation services?
A4: Yes, we provide customisation services including packaging, labelling, and adjusting product specifications to meet specific client requirements.

Q5. How does APPCHEM ensure product quality and stability?
A5: We maintain a rigorous quality control system. All products undergo third-party testing, with detailed COA (Certificate of Analysis) and stability data provided.
Reference
[1]V. Tadić, S. Dobrić et al. "Anti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities of hawthorn berries ethanol extract." Journal of agricultural and food chemistry (2008).
[2]M. Tauchert. "Efficacy and safety of crataegus extract WS 1442 in comparison with placebo in patients with chronic stable New York Heart Association class-III heart failure." American Heart Journal (2002).
[3]G. Zapfe jun. "Clinical efficacy of crataegus extract WS 1442 in congestive heart failure, NYHA class II." Phytomedicine: international journal of phytotherapy and phytopharmacology (2001).
[4]Wang Yuanyuan. Construction of Phospholipid Complexes with Hawthorn Leaf Extract and Investigation of Their Oral Bioavailability [Doctoral Thesis]. Nanjing University of Chinese Medicine, 2022.
[5]S. Grigorakis, Abedalghani Halahlah et al. "Stability of Salvia fruticosa Mill. Polyphenols and antioxidant activity in a citrate-based natural deep eutectic solvent." Nova Biotechnologica et Chimica (2020).