What is HPLC 90% Phloretin Powder?
Phloretin is a naturally occurring dihydrochalcone active compound found in apple peel and leaves, renowned for its exceptional tyrosinase-inhibiting capacity and antioxidant activity. It stands as one of the core functional ingredients for developing premium skin-brightening, anti-ageing skincare products and health foods.
However, the market's commonly available "apple extracts" generally suffer from complex compositions, ambiguous main content, and significant batch-to-batch variability. This poses considerable risks to B2B clients regarding formulation stability, credibility of efficacy claims, and compliance audits.
To address this, we introduce this standardised HPLC 90% Phloretin Powder. It is not merely a raw material but a trusted solution for procurement managers, product development engineers, and quality decision-makers within the plant extract industry. Strictly adhering to international pharmacopoeia standards and ISO quality management systems, this product delivers precise composition, transparent data, and full traceability. We are committed to providing a comprehensive product dossier that presents a complete quality evidence chain, from molecular structure to factory-release reports, serving as a dependable link in your supply chain.
PS: This page focuses on the product Technical Data Sheet.
For product application information, please click Cosmetic Ingredients Phloretin 60-82-2.
For Integrated Supply Chain & Solutions, please click Apple Extract Phloretin Bulk Supply.
What Are the Key Numerical Data for Ingredients?
Physical and Chemical Properties
| Common Name | Phloretin |
| Chemical Name | 2′,4′,6′-Trihydroxy-3-(4-hydroxyphenyl)acetophenone |
| CAS Number | 60-82-2 (Unique Chemical Substance Identifier) |
| Molecular Formula |
C₁₅H₁₄O₅
|
| Molecular Weight | 274.27 g/mol |
| EINECS | 200-488-7 |
| Melting point | 260–262 °C |
| Boiling point | 534.4°C (760 mmHg) |
| Density | 1.4±0.1 g/cm³ (25°C) |
| Flash point | 291.1°C |
| LogP | 2.6 |
| Appearance and Characteristics | Off-white to pale yellow powder, free from lumps and visible foreign matter |
| Solubility | Easily soluble in ethanol, acetone, DMSO, and alkaline aqueous solutions; extremely low solubility in pure water (<0.1%). This characteristic is a key consideration in formulation development (e.g., alcohol-soluble essences, nano-carrier encapsulation) |
| Stability | Recommended storage is in a cool (<25°C), dry (relative humidity <60%), light-protected environment under sealed conditions. Under these conditions, the product has a shelf life of 24 months, with a maximum active ingredient loss of no more than 2% during this period |
Safety and Compliance Criteria
This product's safety standards comprehensively reference regulatory requirements from major markets, including China, the European Union, and the United States. Both internal and third-party laboratories have validated all data.
| Heavy Metal Limits |
Complies with stringent restrictions outlined in the 2020 edition of the Chinese Pharmacopoeia and the EU Cosmetics Regulation (EC) No 1223/2009:
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| Pesticide Residues | Compliant with the multi-residue analysis requirements for plant extracts as per Chapter 2.8.13 of the European Pharmacopoeia. Screening employs GC-MS/MS and LC-MS/MS methods to ensure no detection or levels below the limit of quantification for over 200 common pesticides. |
| Microbial Control |
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| Non-GMO and Non-Irradiated Declaration | This product's raw materials originate from non-genetically modified apple sources. No genetically modified techniques or irradiation sterilisation were employed throughout the entire production and processing stages, with a written declaration provided. |
TDS Guide
A professional TDS not only defines product specifications but also articulates the commercial and scientific rationale behind different choices.
Standard Specification: HPLC ≥ 90%. This industrially pure specification, validated through extensive applications, achieves an optimal balance between efficacy, cost, and formulation compatibility.
| Specification | Typical Content | Cost Implications | Efficacy & Application Differences |
| Standard Grade | 40% - 80% | Economical | Suitable for cost-sensitive foundational products with broad efficacy targeting; formulation loading capacity must be adequately reserved. |
| High-Purity Grade | 90% - 98% | Optimal cost-effectiveness | Defined active components with precisely calculable dosages, ideal for targeted efficacy claims in premium skincare and functional foods |
| Reference Grade | > 98% | High cost | Primarily for laboratory analytical comparison; not recommended for large-scale commercial production. |
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Key Consideration: Selecting different purity grades primarily balances cost, efficacy intensity, and formulation precision. Regardless of your specification, you receive our consistent assurance regarding raw material sourcing, safety testing, and quality control systems. 1. Consistent raw material sourcing: All sourced from non-GMO, standardised cultivation bases. 2. Consistent testing standards: Adherence to equally stringent pesticide residue and heavy metal safety testing protocols. 3. Unified quality control: Manufactured under the same ISO-certified end-to-end quality management system. |
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What's the COA for the Product?
We undertake that every batch of product shall be accompanied by a Certificate of Analysis (COA) compliant with international standards. Furthermore, every analytical result on the COA is traceable to primary records and supports audit verification by clients or third parties.
Note: The COA charts, test items, and other information provided on this page are for illustrative reference only, demonstrating our quality control dimensions and capabilities. The specific COA documentation for actual products (including precise batch numbers, test data, and spectra) shall be subject to the final release by our business specialists(Serrisha: cwj@appchem.cn).
How is Phloretin Powder Produced?
To facilitate your understanding of our production process framework, the diagram below illustrates the key stages from raw materials to finished products.
The flowchart above outlines the primary stages of the process. Please get in touch with us for more detailed production information regarding specific process parameters, solvent recovery rates, and capacity specifications. We shall provide further technical consultation tailored to your specific requirements.
How is Quality Ensured from Source to Product?
The quality management system we have established constitutes a closed-loop ecosystem that encompasses the entire lifecycle, from cultivation and production through testing to release. Its core principles are "prevention-oriented, fully controllable throughout, and data traceable".
Source Control (Upstream)
Standardised Base Management: Collaborating with certified contract farms, we implement Good Agricultural Practices (GAP), conduct annual baseline testing of soil and irrigation water, and regulate the use of agricultural inputs.
Dual Verification of Raw Material Entry: Each batch must be accompanied by a certificate of origin. Upon arrival, materials undergo preliminary QC rapid testing. Only those passing this stage enter the holding area for subsequent comprehensive HPLC fingerprint profiling and pesticide residue screening, ensuring only premium-grade raw materials proceed to production.
Production Process Control (Midstream)
HACCP-Based Critical Point Management: Multiple Critical Control Points (CCPs) are established throughout the production line. For instance, online monitoring during purification (CCP1) and drying (CCP2) ensures processes operate within pre-validated "design space".
Batch Traceability Management: Rigorous implementation of area clearance, material identification, and electronic batch record systems eliminates any potential for confusion or cross-contamination.
Laboratory Quality Assurance (Downstream)
Release Testing and Stability Studies: Each finished batch must undergo comprehensive testing covering all physicochemical and safety parameters. Concurrently, long-term and accelerated stability studies are conducted to scientifically determine shelf life.
Digital Traceability and Continuous Improvement
End-to-End Electronic Traceability System: The MES system enables bidirectional electronic traceability from customer orders through to sales dispatch.
Third-Party Authoritative Validation: Finished products are periodically submitted to international third-party institutions such as SGS and Eurofins for parallel testing, serving as independent validation of the internal quality control system.
Certifications & Support Documents
Our transparent quality commitment and R&D capabilities are underpinned by the following authoritative certifications, patented technologies, and supporting documentation.
System Certification Certificates:
- ISO 22000 Food Safety System Certification
- ISO 9001 Quality Management System Certification
Key Supporting Documentation:
- FDA, KOSHER, HALAL, SC...
- Full-project Quality Inspection Reports (batch-specific)
- Material Safety Data Sheet (MSDS)
- Factory Audit Report Summary
We fully recognise the importance of reviewing original documentation during supplier selection. Should you require access to originals or certified copies of the aforementioned certificates, patent documentation, or batch-specific supporting files for formal supplier evaluation or reference purposes, please contact our dedicated manager. We shall provide full cooperation in supplying the required materials to support your decision-making process.
Applications and Customised Formulation Support
Based on its well-defined mechanism of action, high-purity Phloretin serves as an ideal raw material for developing targeted efficacy products.
Core Efficacy Applications:
- Skin-lightening agent: Effectively inhibits tyrosinase activity, intervening at the source to suppress melanin synthesis.
- Antioxidant: Neutralises free radicals, mitigating skin ageing caused by oxidative stress.
- Soothing ingredient: Helps regulate skin inflammatory responses, alleviating discomfort.
- Transdermal Enhancer: Improves percutaneous absorption of other active ingredients.
Recommended Formulation Strategies:
- Brightening Synergy Protocol: Geniposide + Arbutin/Liquiritin. Multi-pathway synergy targets distinct stages of melanin production for comprehensive skin-brightening effects.
- Antioxidant Repair Protocol: Geniposide + Green Tea Extract/Grape Seed Extract. Establishes a multidimensional antioxidant network, fortifying the skin's inherent defence system against photoaging.
Customised Solutions: Our dedicated application R&D team provides tailored technical support, from ingredient formulation advice and formulation research to sample prototyping, aligned with your specific product concepts (e.g., soothing brightening serums for oily/sensitive skin, or oral beauty beverages). We welcome your enquiries to explore your innovative ideas.
Reference
[1]Yin Shinan, Jiang Hua. Advances in Diagnosis and Treatment of Metabolic Syndrome [J]. Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Diseases, 2018, 20(11): 1121-1123.
[2]Chassaing B., Shreya M.R., Lewis J.D., st al. Colonic microbiota encroachment correlates with dysglycemia in humans. Cell Mol. Gastroenterol. Hepatol. 2017; 4:205-221.
[3]Zhang XY, ChenJ, Yi K, Peng L, Xie J, Gou X, Peng T, Tang L. Phlorizin ameliorates obesity-associated endotoxemia and insulin resistance in high-fat diet-fed miceby targeting the gut microbiota and intestinal barrier integrity. Gut Microbes. 2020 Nov 9; 12(1):1-18. Doi: 10.1080/19490976.2020.1842990. PMID: 33222603; PMCID: PMC7714487.
