Indole-3-Carbinol Powder

Indole-3-Carbinol Powder is a naturally occurring plant compound primarily found in cruciferous vegetables such as broccoli, kale, and Chinese cabbage. Indole-3-carbinol (I3C) is a key bioactive component in these vegetables. Owing to its extensive applications in antioxidant, anti-cancer, hormone regulation, and health protection, it has become a significant raw material in the dietary supplement and functional health product sectors. As a naturally derived plant-based active ingredient, Indole-3-Carbinol Powder exerts notable effects on oestrogen metabolism, immune system support, and anti-inflammatory activity within the body.

APPCHEM's Indole-3-Carbinol Powder is extracted from cruciferous vegetables through advanced solvent extraction and purification processes, ensuring high purity and potency throughout extraction. We employ standardised extraction technology to precisely control the indole-3-carbinol content in each batch, guaranteeing stability, purity, and batch consistency as a functional ingredient that meets the requirements for high-quality dietary supplements.

Indole-3-Carbinol Powder is typically supplied in powder form, offering excellent formulation compatibility and processing adaptability. It is suitable for various dietary supplement dosage forms, including tablets, capsules, and granules. In practical applications, Indole-3-Carbinol Powder is frequently incorporated into formulations targeting women's health, hormonal balance, antioxidant support, and anti-cancer assistance. It may be synergistically combined with other botanical extracts (such as grape seed extract, green tea extract) and nutritional components (such as selenium, vitamin D3) to help enhance health and prevent ageing.

XI'AN APP-CHEM BIO (TECH) CO., LTD. (APPCHEM) provides Indole-3-Carbinol Powder utilising a mature, reproducible industrial plant extraction process, comprising the following principal steps:

1. Washing
2. Filtering
3. Removing impurities
4. Drying: to prevent high-temperature damage to thermosensitive active ingredients, especially volatile oils.
5. Crushing: (such as 80 mesh) to increase the contact area with the solvent and improve extraction efficiency.
6. Extraction
7. Solid-liquid separation
8. Purification
9. Concentrate
10. Drying
11. Smashing
12. Packaging
13. Finished product

Indole-3-Carbinol Powder, a notable dietary supplement ingredient, derives its efficacy from its profound and multi-targeted biological mechanisms. Through its conversion within the body, it activates a series of molecular pathways crucial for maintaining cellular health and physiological equilibrium.

• Regulation of Healthy Oestrogen Metabolism

Indole-3-Carbinol Powder is most celebrated for its potent regulatory capacity over oestrogen metabolism, forming the foundation of its support for both female and male health. I3C and its primary active metabolite, DIM, act as inducers of the cytochrome P450 (CYP) enzyme system in the liver, particularly CYP1A1, CYP1A2, and CYP1B1. The enhanced activity of these enzymes significantly promotes the 2-hydroxylation pathway of oestrogen metabolism, thereby increasing the ratio of the protective 2-OHE1 to the potentially higher-risk 16α-OHE1 (2-OHE1/16α-OHE1 ratio) within the body. This mechanism not only aids in maintaining endocrine system balance but also constitutes a key component of I3C's chemopreventive potential.

• Cellular Health Guardian

Beyond regulating hormone metabolism, Indole-3-Carbinol Powder and its derivatives exert direct effects on cells. By modulating growth, differentiation, and death through multiple signalling pathways, they demonstrate potential as cellular health maintainers. I3C/DIM can intervene in the cell cycle process, arresting abnormal cells at the G1 or G2/M phases to inhibit uncontrolled proliferation. This is achieved by regulating the expression of cyclins, cyclin-dependent kinases (CDKs), and their inhibitors (such as p21 and p27). These combined actions form the foundation for maintaining normal cellular function and structure.

• Activation of Biphasic Detoxification Enzymes

Indole-3-Carbinol Powder aids the body in more effectively neutralising and eliminating these harmful substances by enhancing the liver's detoxification capacity. I3C can simultaneously activate Phase I and Phase II detoxification enzymes. I3C induces the cytochrome P450 enzyme system, which is responsible for converting lipophilic toxins into more readily reactive intermediate metabolites. Crucially, I3C powerfully induces Phase II detoxification enzymes such as glutathione S-transferases (GSTs) and quinone reductase (NQO1). These enzymes bind the reactive intermediates produced by Phase I to endogenous molecules (such as glutathione), significantly increasing their water solubility and enabling safe excretion via urine or bile. Through this dual activation mechanism, Indole-3-Carbinol Powder markedly enhances the body's overall capacity to manage environmental toxins and metabolic waste.

• Antioxidant and Anti-inflammatory Effects

Indole-3-Carbinol Powder and its metabolites directly scavenge free radicals. They also enhance cellular antioxidant defences by activating the Nrf2 signalling pathway, thereby upregulating the expression of various antioxidant enzymes such as heme oxygenase-1. Furthermore, it inhibits the production of pro-inflammatory mediators such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), thereby alleviating unnecessary inflammatory responses.

With its well-defined scientific mechanism and extensive health benefits, Indole-3-Carbinol (I3C) Powder offers diverse and precise applications within the dietary supplement market, catering to the specific health requirements of various consumer groups. Our high-purity I3C powder is an ideal choice for developing the following premium dietary supplement products, aligning perfectly with our product positioning:

• Women's Health Series

Women's Health Series focuses on supporting healthy oestrogen metabolism and maintaining the long-term health of breast and cervical cells.

Target Audience: Women of all ages concerned with breast health, seeking to maintain regular menstrual cycles, and desiring hormonal balance support around menopause.

Formulation Synergy: Can be combined with ingredients such as DIM, lignans, calcium D-gluconate, and green tea extract (EGCG) to enhance support for hormonal metabolic pathways.

• Men's Health Series

Men's Health Series is designed to support prostate health and maintain a healthy testosterone-oestrogen balance.

Target Audience: Middle-aged and older men prioritising prostate health and vitality maintenance.

Formulation Synergy: Combines with classic male health ingredients like saw palmetto extract, lycopene, pumpkin seed extract, and zinc for comprehensive prostate support.

• Liver Health & Detoxification Series

Liver Health & Detoxification Series Strengthens the liver's dual-phase detoxification function, aiding the body in eliminating environmental toxins and metabolic waste.

Target audience: Individuals living in urban environments, frequently exposed to chemicals, or seeking regular bodily purification.

Formula Synergy: Works synergistically with silymarin (milk thistle extract), N-acetylcysteine (NAC), artichoke extract, curcumin, and others to deliver comprehensive nutritional support for the liver.

• Cellular Health & Healthy Ageing Series

Cellular Health & Healthy Ageing Series is designed to protect cells from oxidative damage, support normal cellular lifecycles, and promote healthy ageing.

Target Audience: All adults seeking to maintain long-term cellular vitality and overall health through nutritional intervention.

Formulation Synergy: Can be combined with resveratrol, coenzyme Q10, PQQ (pyrroloquinoline quinone), and a variety of antioxidant vitamins and minerals to create a robust cellular protection formula.

The product is mainly in the form of standardised plant extract powder and supports customisation of content, making it easy for OEM/ODM customers to design formulas.

Security statement：

Our company guarantees that the goods sent are safe, non-flammable, and non-explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company.

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Long-term cooperative logistics companies include international logistics companies such as DHL, FedEx, UPS, etc.

The regular bulk packaging of the product is a 25kg plastic bag and a cardboard drum. The sample is packaged in an inner aluminium foil bag and an outer plastic bag, supporting customised packaging solutions.

XI'AN APP-CHEM BIO (TECH) CO., LTD. (APPCHEM) regularly participates in international raw material exhibitions such as CPHI, SSW, and In Cosmetics Asia, and establishes long-term cooperative relationships with global customers.

Q1. How is the purity of this product verified?
A1: We employ authoritative analytical methods such as High Performance Liquid Chromatography (HPLC) and Ultraviolet Spectroscopy (UV) to ensure a content of 99%.

Q2. What is the minimum order quantity for Indole-3-Carbinol Powder?
A2: Our minimum order quantity (MOQ) varies by product and specific requirements, and is typically negotiable. Please contact us for detailed information.

Q3. What is the delivery timeframe for the product?
A3: Delivery times depend on order volume and product type. Generally, we arrange production and dispatch promptly upon order confirmation.

Q4. Does APPCHEM offer customisation services?
A4: Yes, we provide customisation services including packaging, labelling, and adjusting product specifications to meet specific client requirements.

Q5. How does APPCHEM ensure product quality and stability?
A5: We maintain a rigorous quality control system. All products undergo third-party testing, with detailed COA (Certificate of Analysis) and stability data provided.
Reference
[1]M. Bell, P. Crowley-Nowick et al. "Placebo-controlled trial of indole-3-carbinol in the treatment of CIN." Gynecologic oncology (2000).
[2]Carolyn M. Cover, S. Hsieh et al. "Indole-3-carbinol Inhibits the Expression of Cyclin-dependent Kinase-6 and Induces a G1 Cell Cycle Arrest of Human Breast Cancer Cells Independent of Estrogen Receptor Signalling. The Journal of Biological Chemistry (1998).
[3]Wenxiu Zheng, Lin Ren et al. "Encapsulation of indole-3-carbinol in Pickering emulsions stabilised by OSA-modified high amylose corn starch: Preparation, characterisation and storage stability properties." Food Chemistry (2022).
[4]F. Fares. "The Anti-Carcinogenic Effect of Indole-3-Carbinol and 3, 3'-Diindolylmethane and their Mechanism of Action." Medicinal Chemistry (2014).
[5]Toxicology studies of indole-3-carbinol in F344/N rats and B6C3F1/N mice and toxicology and carcinogenesis studies of indole-3-carbinol in Harlan Sprague Dawley rats and B6C3F1/N mice (gavage studies). National Toxicology Program technical report series (2017).