Sophora Japonica Extract

Sophora japonica extract is a yellow powdery product obtained by extracting, separating, and refining the dried flower buds of Leguminosae sophora japonica. Sophora Japonica Extract Powder is a type of dietary supplement that is derived from the Sophora Japonica plant, native to China, Korea, and Japan. The plant grows to a height of about 20 meters and produces beautiful yellow flowers. The Sophora Japonica plant has been used for thousands of years in traditional Chinese medicine for its therapeutic properties. 

• Raw material sources and quality control

The production raw materials for Sophora Japonica Extract mainly use dried buds of locust trees grown in northern China, especially in provinces such as Shaanxi, Henan, and Shandong. The harvesting period is concentrated in July and August each year when the buds are not yet open.

• Processing technology

After receiving the raw materials, the appearance, physical and chemical, and microbiological inspections are carried out first. Qualified products enter the treatment process:

 Removing impurities and cleaning
 Drying
 Smashing
 Degreasing treatment
 Extraction
 Solid liquid separation and purification
 Concentration and drying
 Finished product

4.1 Antioxidant and free radical scavenging effects
The core efficacy of Sophora japonica Extract comes from its powerful antioxidant capacity. The ortho-dihydroxy groups in the molecular structure of rutin and quercetin can efficiently scavenge superoxide anions (O ₂⁻), hydroxyl radicals (· OH), and peroxynitrite (ONOO ⁻).
4.2 Anti-inflammatory and immune regulatory functions
In the LPS-induced macrophage RAW264.7 inflammation model, Sophora japonica Extract (100 μ g/mL) inhibited NO production by 68.5% and TNF-α secretion by 52.3%. Its mechanism of action involves multiple signalling pathways: inhibition of the NF-κB pathway; MAPK pathway regulation; NLRP3 inflammasome inhibition
4.3 Cardiovascular and Microcirculation Protection
Rutin can enhance the resistance of capillaries, reduce their permeability, and fragility. Its mechanism of action includes:
Increase NO production through PI3K/Akt/eNOS pathway, improve vascular endothelium-dependent relaxation function, reduce serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), increase high-density lipoprotein cholesterol (HDL-C), and improve atherosclerosis index.

Sophora japonica Extract is the core ingredient for developing functional dietary supplements, suitable for the following health claims:

• Antioxidant formula: compounded with vitamin C and vitamin E to form a synergistic antioxidant system
• Cardiovascular Health: Combined with Coenzyme Q10 and Omega-3 Fatty Acids for Maintaining Normal Blood Pressure and Cholesterol Levels
• Sports nutrition: Relieve oxidative stress and inflammatory reactions caused by high-intensity exercise
• Menopausal syndrome: improving vasomotor symptoms and enhancing quality of life

Common product forms include:

• Raw material powder: Rutin content of 80%, 95%, 98% HPLC
• Capsules: Each capsule contains a standardised extract of 250-500 mg, usually with quercetin dihydrate added as the active form
• Tablets: Wet granulation and compression are used, with the addition of auxiliary materials such as microcrystalline cellulose and cross-linked carboxymethyl cellulose sodium
• Liquid beverage: developed as a 10% concentration oral solution, requiring the addition of cyclodextrin inclusion to enhance solubility

Security statement：

Our company guarantees that the goods sent are safe, non-flammable, and non-explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company.

Tags: Sophora Japonica Extract, Rutin Powder, Rutin Powder manufacturers, suppliers, factory, wholesale, best, price, buy, for sale, bulk.

Reference

[1]STUDY OF THE EXTRACTION KINETICS OF FLAVONOIDS FROM THE FRUITS OF SOPHORA JAPONICA L. WITH SUNFLOWER OIL. Liubov Pelekova et al. [2024]

[2]DEVELOPMENT OF REVERSED-PHASE HPLC METHOD FOR ISOLATION AND QUANTIFICATION OF RUTIN AND QUERCETIN FROM FLOWER BUDS OF SOPHORA JAPONICA L. Mengliev M.U. et al. [2024-10-03]

[3]MALE REPRODUCTIVE TOXICITY ASSOCIATED WITH SOPHORA JAPONICA TREATMENT: EVALUATION OF CELLULAR AND MOLECULAR EVENTS IN VITRO. P. SOLEK et al. [2018]

[4]Estrogenic activity of a naringinase-treated extract of Sophora japonica cultivated in Egypt. Ali M. El-Halawany et al. [2009-12-29]

[5]Na Guo, Zhuo Chen et al. "Sophora japonica L. bioactives: Chemistry, sources, and processing techniques." Food Frontiers (2024). [2024-02-13]