What is 90% Phlorizin Powder HPLC Test?
Phlorizin is a naturally occurring dihydrochalcone glycoside compound found in apple bark, root bark, and fruit, representing the glucoside form of phloretin. As one of the core bioactive components of apple polyphenols, Phlorizin is renowned for its unique sodium-glucose cotransporter (SGLT) inhibitory activity and exceptional antioxidant properties. It serves as a key ingredient in developing blood sugar-regulating health foods, functional beverages, and premium skin-brightening skincare products.
We present this standardised HPLC 90% Phlorizin powder. It is not merely a raw material, but a trusted solution for procurement managers, product development engineers, and quality decision-makers within the plant extract industry. We are committed to providing a comprehensive quality evidence chain, from molecular structure to factory reports, through this detailed product dossier, serving as a reliable link in your supply chain.
PS: This page focuses on the product Technical Data Sheet.
For product application information, please click Phlorizin 60-82-1 Blood Glucose Management Ingredient.
For Sample & Supply Chain Solutions, please click Apple Extract Phlorizin Factory Sample.
What Are the Key Numerical Data for Phlorizin?
Physical and Chemical Properties
| Common Name | Phlorizin/Phloridzin |
| Chemical Name | 1-(2-(β-D-glucopyranosyloxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)acetone |
| CAS Number | 60-81-1 (Unique Chemical Substance Identifier) |
| Molecular Formula |
C₂₁H₂₄O₁₀
|
| Molecular Weight | 436.41 g/mol |
| EINECS | 200-487-1 |
| Melting point | 113-114 °C(lit.) |
| Boiling point | 468.89°C (rough estimate) |
| Density | 1.3178 (rough estimate) |
| HS Code | 29389090 |
| LogP | 0.452 (est) |
| Appearance and Characteristics | Off-white to pale yellow powder, free from lumps and visible foreign matter |
| Solubility | Soluble in hot water, ethanol, methanol, acetone, and ethyl acetate; slightly soluble in cold water. At low concentrations, it exhibits good water solubility; At high concentrations (such as 90%), its water solubility is poor. |
| Stability | Recommended storage is in a cool (<25°C), dry (relative humidity <60%), light-protected environment under sealed conditions. Under these conditions, the product has a shelf life of 24 months, with a maximum active ingredient loss of no more than 2% during this period |
Safety and Compliance Criteria
This product's safety standards comprehensively reference regulatory requirements from major markets, including China, the European Union, and the United States. Both internal and third-party laboratories have validated all data.
| Heavy Metal Limits |
Complies with stringent restrictions outlined in the 2025 edition of the Chinese Pharmacopoeia: Lead (Pb) ≤ 10 mg/kg Arsenic (As) ≤ 3 mg/kg Cadmium (Cd) ≤ 1 mg/kg Mercury (Hg) ≤ 1 mg/kg |
| Pesticide Residues | Screening employs GC-MS/MS and LC-MS/MS methods to ensure no detection or levels below the limit of quantification for over 200 common pesticides. |
| Microbial Control |
Total Aerobic Bacteria ≤ 1,000 CFU/g Total mould and yeast count ≤ 100 CFU/g Not detectable: Escherichia coli, Salmonella spp., Staphylococcus aureus |
| Non-GMO and Non-Irradiated Declaration | This product's raw materials originate from non-genetically modified apple sources. No genetically modified techniques or irradiation sterilisation were employed throughout the entire production and processing stages, with a written declaration provided. |
TDS Guide
A professional TDS not only defines product specifications but also articulates the commercial and scientific rationale behind different choices.
Standard Specification: HPLC ≥ 90%. This industrially pure specification, validated through extensive applications, achieves an optimal balance between efficacy, cost, and formulation compatibility.
| Specification | Typical Content | Cost Implications | Efficacy & Application Differences |
| Standard Grade | 40% - 80% | Economical | Suitable for cost-sensitive basic health products, such as common dietary supplements. As one of the compound ingredients, rhein has a broad spectrum of efficacy. |
| High-Purity Grade | 90% - 98% | Optimal cost-effectiveness | Active ingredients are clearly defined, with precise calculation of addition levels. Suitable for functional foods targeting blood sugar regulation/weight management and premium skincare products (brightening and anti-ageing serums), it is an ideal choice for achieving explicit efficacy claims. |
| Reference Grade | > 98% | High cost | Primarily used for laboratory analytical comparisons, content determination, or pharmacological activity studies. |
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Key Consideration: Selecting different purity grades primarily balances cost, efficacy intensity, and formulation precision. Regardless of your specification choice, you receive our consistent assurance in raw material sourcing, safety testing, and quality control systems. 1. Consistent raw material sourcing: All sourced from non-GMO, standardised cultivation bases. 2. Consistent testing standards: Adherence to equally stringent pesticide residue and heavy metal safety testing protocols. 3. Unified quality control: Manufactured under the same ISO-certified end-to-end quality management system. |
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What's the COA for Phlorizin?
We undertake that every batch of product shall be accompanied by a Certificate of Analysis (COA) compliant with international standards. Furthermore, every analytical result on the COA is traceable to primary records and supports audit verification by clients or third parties.
Note: The COA charts, test items, and other information provided on this page are for illustrative reference only, demonstrating our quality control dimensions and capabilities. The specific COA documentation for actual products (including precise batch numbers, test data, and spectra) shall be subject to the final release by our business specialists(Serrisha: cwj@appchem.cn).
How is Phlorizin Powder Produced?
To facilitate your understanding of our production process framework, the diagram below illustrates the key stages from raw materials to finished products.
The flowchart above outlines the primary stages of the process. Please contact us for more detailed production information regarding specific process parameters, solvent recovery rates, and capacity specifications. We shall provide further technical consultation tailored to your specific requirements.
How is Quality Ensured from Source to Product?
The quality management system we have established constitutes a closed-loop ecosystem encompassing the entire lifecycle from cultivation and production through testing to release. Its core principles are "prevention-oriented, fully controllable throughout, and data traceable".
Source Control (Upstream)
Standardised Base Management: Collaborating with certified contract farms, implementing Good Agricultural Practices, conducting annual baseline testing of soil and irrigation water, and regulating the use of agricultural inputs. Raw material sources include apple tree root bark, stems, branches, leaves, and fruit peel residues.
Dual Verification of Raw Material Entry: Each batch of raw materials must be accompanied by a certificate of origin. Upon arrival at the facility, materials undergo preliminary QC screening (microscopic identification, TLC rapid screening). Only materials passing this stage are admitted to the holding warehouse for subsequent comprehensive HPLC fingerprint profiling and pesticide residue screening, ensuring only premium-quality raw materials enter production.
Production Process Control (Midstream)
HACCP-Based Critical Point Management: Multiple Critical Control Points (CCPs) are established throughout the production line. For instance, online monitoring during purification and drying ensures processes operate within a pre-validated "design space".
Batch Traceability Management: Rigorous implementation of area clearance, material identification, and electronic batch record systems eliminates any potential for confusion or cross-contamination.
Laboratory Quality Assurance (Downstream)
Release Testing and Stability Studies: Each batch of finished products must undergo comprehensive testing covering all physicochemical and safety parameters. Equipped with advanced analytical instruments including HPLC, UV and GC, we assess multiple quality indicators such as active ingredient content, solvent residues, heavy metals and microbial levels. Concurrently, long-term and accelerated stability trials are conducted in accordance with internal quality control guidelines to scientifically determine shelf life.
Digital Traceability and Continuous Improvement
End-to-End Electronic Traceability System: The MES system enables bidirectional electronic traceability from customer orders through to sales dispatch.
Third-Party Authoritative Validation: Finished products are periodically submitted to international third-party institutions such as SGS and Eurofins for parallel testing, serving as independent validation of the internal quality control system.
What Certifications and Support Documents Are Available?
Our transparent quality commitment and R&D capabilities are underpinned by the following authoritative certifications, patented technologies, and supporting documentation.
System Certification Certificates:
- ISO 22000 Food Safety System Certification
- ISO 9001 Quality Management System Certification
Key Supporting Documentation:
- FDA, KOSHER, HALAL, SC...
- Full-project Quality Inspection Reports (batch-specific)
- Material Safety Data Sheet (MSDS)
- Factory Audit Report Summary
We fully recognise the importance of reviewing original documentation during supplier selection. Should you require access to originals or certified copies of the aforementioned certificates, patent documentation, or batch-specific supporting files for formal supplier evaluation or reference purposes, please contact our dedicated manager. We shall provide full cooperation in supplying the required materials to support your decision-making process.
What Applications and Custom Formulation Support Are Available?
Based on its well-defined mechanism of action, high-purity phlorizin serves as an ideal raw material for developing targeted functional products.
Core Functional Applications:
- Blood Glucose Reduction and Weight Management: Phlorizin acts as a natural inhibitor of the sodium-glucose cotransporter (SGLT), competitively suppressing glucose reabsorption in the intestines and kidneys. This assists in lowering fasting blood glucose levels and supports healthy glucose metabolism. This constitutes the core mechanism for developing functional foods targeting prediabetes and weight management.
- Skin Whitening Agent: As the glycoside precursor to Phloretin, it converts into Phloretin to deliver whitening effects, effectively inhibiting tyrosinase activity and intervening at the source of melanin synthesis.
- Potent Antioxidant: Possesses 2-6 times the antioxidant capacity of vitamin C, scavenging free radicals to mitigate oxidative stress-induced skin ageing and shield cells from oxidative damage.
- Hydration and Permeability Enhancement: Exhibits exceptional water absorption and retention properties, absorbing 4-5 times its own weight in moisture. Simultaneously promotes the absorption and utilisation of other functional ingredients within formulations.
- Anti-inflammatory and Antibacterial: Research indicates anti-inflammatory, anti-allergic, and antimicrobial properties.
Recommended Formulation Schemes:
- Glucose Regulation/Weight Management: Phlorizin + Chromium + Cinnamon Extract/Cinnamic Acid. Multi-pathway synergy targeting glucose absorption, insulin sensitivity, and carbohydrate metabolism for comprehensive blood sugar management support.
- Brightening & Anti-Ageing Protocol: Phlorizin + Vitamin C/Arbutin + Green Tea Extract. Establishes a multi-layered skin defence network through "melanin inhibition + antioxidant protection + enhanced penetration", fortifying the skin's natural defences against photoaging.
Customised Solutions: Our dedicated application R&D team provides tailored technical support-from ingredient formulation recommendations and dosage form studies to sample prototyping-aligned with your specific product concepts (e.g., daily nutritional drinks for glucose metabolism support, brightening serums for oily/sensitive skin). We offer customisation services ranging from milligram to kilogram scale.
Contact Us: For specific batch COAs, TDS, process details, samples, or to discuss bespoke requirements, please contact our technical sales team at any time. Complimentary samples are available for testing; please enquire before placing orders.
Reference
[1]Li Rongtao, Liu Jiechao, Jiao Zhonggao, et al. Determination of Rhamnose in Apple Branches and Leaves by RP-HPLC. Journal of Food Industry Science and Technology, 2009, 000(012):385-388. DOI: CNKI:SUN:SPKJ.0.2009-12-118.
[2]Zhao Yanmin, Wang Jiao, Song Guangming, et al. Study on the Variation of Rutin and Rutinic Acid Content in Apple Tree Branches and Leaves [J]. Food Research and Development, 2013, 34(7):4. DOI:10.3969/j.issn.1005-6521.2013.07.025.
[3]Meng Xiangtao. Study on the Hypoglycaemic Effects of Polyphenolic Compounds in Apple Tree Branches [D]. Hebei Medical University, 2014. DOI: 10.7666/d.Y2582406.
