100% Natural Birch Bark Extract Powder Birch Bark Extract Betulin

Natural Betulin Powder is a white crystalline powder extracted and purified from the outer skin of Betula platyphylla. Its core active ingredient is Betulin, chemical name: lup-20 (29) - ene-3 β, 28 diol, molecular formula: C₃₀H₅₀O₂, molecular weight: 442.72 g/mol.
This product is positioned as a high-end dietary supplement raw material, and its purity is usually required to be ≥ 95% (HPLC detection), meeting the relevant quality requirements of the International Cosmetic Ingredient Standards (ICID) and the United States Pharmacopeia (USP).

1.1 Natural sources and resource distribution
Natural Betulin Powder is mainly enriched in the outer bark of birch trees, and its biosynthetic pathway is derived from the mevalonic acid pathway, which is cyclized by squalene to form a lupine skeleton. According to industrial data, European birch (Betula penula) and Asian birch (Betula platyphylla) are the main sources of natural Betuline for industrial and commercial production. Birch forest resources in Russia, Finland, and Northeast China constitute the world's three major raw material supply bases.

Modern plant chemistry research has shown that Natural Betulin Powder exists in two forms in birch bark: free and esterified, with the free state accounting for over 85% and easily obtainable through solvent extraction.

• Anti-inflammatory effect: In the mouse macrophage RAW264.7 inflammation model induced by lipopolysaccharide (LPS), Betulin significantly inhibited NO production at a concentration of 10 μ M, with an inhibition rate of 68.3% (p<0.01) and an IC50 value of 7.8 μ M. Molecular mechanism studies have shown that Betulin downregulates the mRNA expression of pro-inflammatory cytokines such as TNF - α, IL-6, and IL-1 β by blocking the IKK β/I κ B α/NF - κ B signaling pathway.
• Antioxidant efficacy: DPPH free radical scavenging experiments showed that Betulin has an EC ₅₀ value of 18.5 μ g/mL, which is weaker than ascorbic acid (EC ₅₀ 4.2 μ g/mL), but exhibits excellent protection against oxidative stress at the cellular level. In the H₂O₂-induced oxidative damage model of human skin fibroblasts, pretreatment with 20 μM Metulin increased cell survival rate from 52% in the control group to 89% (detected by MTT assay), and its protective effect is closely related to upregulation of the Nrf2/HO-1 antioxidant pathway.
• Immune regulatory effect: In a cyclophosphamide-induced immunosuppression mouse model, continuous gavage of Betulin 50 mg/kg body weight for 14 days can restore the spleen index to 87.3% of normal levels, increase serum IgG levels by 2.1 times, and significantly enhance delayed type hypersensitivity (DTH) reactions. Flow cytometry analysis showed that Betulin can promote the balance of the CD4 ⁺/CD8 ⁺ T cell ratio and enhance the type of immune response.

Natural Betulin powder is mainly used in four segmented markets in the field of dietary supplements:

As the core active ingredient, the recommended dosage is 30-50 mg per day, usually combined with traditional immune nutrients such as vitamin C and zinc.

According to the revised recommendations of the 2023 edition of the "Reference Intake of Dietary Nutrients for Chinese Residents", the supplementary dose of triterpenoids should be controlled within a safe range, and the NOAEL (No Observed Adverse Effect Level) of Betulin is 500 mg/kg body weight (90-day subchronic toxicity study in rats). Based on this, the EU EFSA has set a daily allowable intake (ADI) of 0.5 mg/kg body weight, and the upper limit of safe daily intake for 60 kg adults is 30 mg.

Betulin works similarly to nonsteroidal anti-inflammatory drugs by inhibiting COX-2 enzyme activity (IC₅₀=12.4 μM) in response to muscle micro injuries and chronic inflammation caused by exercise, but without gastrointestinal side effects. The target audience for this type of product is high-intensity athletes and middle-aged and elderly arthritis patients. Clinical studies have shown that continuous supplementation for 8 weeks can significantly reduce serum C-reactive protein (CRP) levels by 35.6%.

Combining its Nrf2 pathway activation characteristics, Betulin forms a synergistic effect with coenzyme Q10 and resveratrol in anti-aging formulas. In vitro experiments have shown that when Betulin is combined with resveratrol in a 1:1 ratio, its promotion effect on collagen synthesis in fibroblasts is increased by 1.8 times, demonstrating a significant synergistic antioxidant index (CSI=1.72).

Security statement：

Our company guarantees that the goods sent are safe, non-flammable, and non-explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company.

QUALIFICATIONS of BON：

ISO9001

ISO22000

QS

Member of IFEAT

Member of the China Chamber of Commerce of Medicine & Health Products & Exporters

KOSHER Certificate

HALAL Certificate

Reference
[1]BALTIC POLYMER SYMPOSIUM 2015. Riga Technical University.[2018-09-16]
[2]I Ogólnopolska Konferencja Naukowa Kosmotrend Naturalne surowce kosmetyczne. Wydział Chemiczny Politechniki Śląskiej.[2024-06-27]
[3]An overview of betulin: botanical source, derivatives, and biological potential: Mini Review. Aanchal Loshali et al.[2024-02-24]
[4]Research Progress in the Promising Natural Product-Betulin. Qingfeng Meng et al.[2018-08-21]
[5]Polymers from the Natural Product Betulin: A Microstructural Investigation. Jekaterina Jeromenok.[2012-12-03]

Hot Tags: natural betulin powder, China natural betulin powder manufacturers, factory, noni liquid dietary supplement, clary sage oil to bring on labour nhs, clary sage and sandalwood, nutritional supplements for depression, high quality nutritional supplements, b12 dietary supplement