What is Silybin Milk Thistle Extract?
Silybin Milk Thistle Extract is a powerful antioxidant that exhibits a range of health-promoting benefits. Our Silybin Powder is derived from the highest quality milk thistle seeds, using the latest technology in extraction and purification techniques. Our product is free from any synthetic additives, chemicals, or preservatives, making it a safe and natural choice for health-conscious consumers.
| Specification: |
| ●Milk Thistle Extract: UV 80% HPLC30%-60% ●Silybin: HPLC 80%-98% (Extraction solution: acetone, ethyl acetate, ethanol) |
| Melting point: 164-174ºC |
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Molecular formula: C25H22O10 |
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Molecular weight: 482.44 |
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EINECS/ELINCS Registration Number: 245-302-5 |
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Structural formula:
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Certificate Of Analysis (COA)
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Product Name |
Silybin |
Botanical Source |
Silybum marianum L. |
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CAS No. |
22888-70-6 |
Plant Part |
Seed |
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ITEM |
SPECIFICATION |
RESULT |
TEST METHOD |
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Physical Description |
|||
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Appearance |
Off White or White Powder |
Conforms |
Visual |
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Odor |
Characteristic |
Conforms |
Organoleptic |
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Taste |
Characteristic |
Conforms |
Olfactory |
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Particle size |
NLT 95% through 80 mesh |
Conforms |
CP2015 |
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Identification |
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TLC test |
The fingerprint should comply with the standard chromatogram |
Conforms |
TLC |
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Chemical Tests |
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Silybin |
≥98.0% |
98.22% |
HPLC |
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Loss on drying |
≤5.0% |
2.11% |
CP2025 (105 oC, 3 h) |
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Ash |
≤1.0% |
0.13% |
CP2025 (600 oC, 4 h) |
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Heavy Metals |
≤20 ppm |
Conforms |
CP2025 |
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Lead (Pb) |
≤1 ppm |
Conforms |
CP2025(AAS) |
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Arsenic (As) |
≤0.5 ppm |
Conforms |
CP2025(AAS) |
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Cadmium (Cd) |
≤0.5 ppm |
Conforms |
CP2025(AAS) |
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Mercury (Hg) |
≤0.5 ppm |
Conforms |
CP2025(AAS) |
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Microbiology Control |
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Aerobic bacterial count |
≤1,000 cfu/g |
Conforms |
CP2025 |
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Total Yeast & Mold |
≤100 cfu/g |
Conforms |
CP2025 |
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Escherichia coli |
Negative |
Conforms |
CP2025 |
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Salmonella |
Negative |
Conforms |
CP2025 |
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Conclusion |
Conforms to specification |
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Is Silybin Milk Thistle Extract Effective?
As a dietary supplement ingredient, the core value of Silymarin extract lies in its clear health benefits, which have been scientifically supported by numerous preclinical and clinical studies. Its mechanism of action is complex and multi-target, mainly focused on liver protection, antioxidant, anti-inflammatory, and metabolic regulation.
benefits of Silybin Milk Thistle Extract
Excellent hepatoprotective effect
Silymarin is a powerful antioxidant that can directly eliminate various reactive oxygen species (ROS) and inhibit the enzyme system responsible for producing free radicals. At the same time, it can significantly enhance the endogenous antioxidant defense system of liver cells.
- Cell membrane stability and antitoxin resistance
- Promote protein synthesis and liver cell regeneration
Powerful anti-inflammatory and immune regulatory effects
Chronic inflammation is a key driving factor in the progression of various liver diseases. Silymarin exhibits significant anti-inflammatory activity. Silymarin can inhibit the activation of the nuclear factor kappa B (NF-κB) signaling pathway. In addition, it can regulate the Nrf2 signaling pathway, further enhancing the protective ability of cells.
Metabolic regulatory potential
Silymarin may exert its effects by improving insulin sensitivity and regulating lipid metabolism. It can affect key enzymes involved in fatty acid synthesis and oxidation, and may regulate cellular energy balance by activating energy metabolism-sensing pathways such as AMPK.
In summary, the efficacy of Silymarin extract as a dietary supplement material is based on a solid scientific foundation. Its multi-target and multi-pathway mechanism of action makes it have broad application prospects in maintaining liver health, combating oxidative stress and inflammation, and regulating metabolism.
Why Choose APPCHEM?
As a manufacturer located in China, I am proud to introduce our latest product – Silybin Milk Thistle Extract. Our Natural Silybin Powder is a high-quality product that has undergone rigorous testing and quality control measures to ensure its efficacy and safety. In this product introduction, I will provide an overview of our Silybin Milk Thistle Extract, its benefits, and how it can help merchants boost their business.
We are Milk Thistle Extract experts.
APPCHEM is recognized as a world leader in Silybin Milk Thistle Extract and offers products and services of exceptional quality.
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5K +Completed Projects5k complete work
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30 +Our ExpertMilk Thistle Extract
As a manufacturer located in China, we take pride in the quality and efficacy of our Silybin Powder, and we are confident that merchants worldwide will find it a valuable product to add to their inventory. With extensive marketing activities, merchants can expect to increase their customer base and revenue by introducing this product.
Certificates
Security statement：
Our company guarantees that the goods sent are safe, non-flammable, and non-explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company.
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FAQ
Q: What is the difference between Silybin and Silymarin?
A: Silymarin is a general term for a group of active compounds extracted from the seeds of Silymarin, which is a complex. Silybin is the most abundant (about 50-70%) and biologically active single component in silymarin. Therefore, high-purity Silymarin extract is considered a more precise and effective supplement ingredient.
Q: Is it safe to take dietary supplements containing silibinin?
A: Yes, it is very safe at the recommended dosage. Silymarin has excellent tolerability and has been recognized for its safety by multiple international authorities, including the US FDA, European EMA, and Health Canada. Very few people may experience mild gastrointestinal reactions.
Q: What kind of people are suitable for taking Silymarin supplements?
A: Suitable for people who are concerned about liver health, especially those who frequently drink alcohol, stay up late, have greasy diets, take medication for a long time, or live in an environmentally polluted area. At the same time, it is also applicable to people who wish to enhance their antioxidant capacity, delay aging, and assist in managing metabolic health.
Q: How long does it take to see the effect?
A: As a dietary supplement, the effect of silibinin gradually accumulates. The specific onset time varies depending on individual physical condition, lifestyle habits, and health status. It is generally recommended to continue taking it for at least 4-12 weeks and adopt a healthy lifestyle to achieve optimal results.
Q: Can Silymarin supplements be taken together with other medications or supplements?
A: Silymarin may affect the activity of certain drug-metabolizing enzymes in the liver, such as the cytochrome P450 enzyme system, and theoretically may interact with certain drugs. If you are taking prescription drugs, especially those for liver metabolism, it is recommended to consult a doctor or pharmacist before taking them.
Q: There is a wide variety of milk thistle products on the market. How to choose?
A: When choosing, attention should be paid to the following points: ① Standardized content: Choose products that clearly indicate the content of the core active ingredient "Silybin", not just "Silymarin" or "Silymarin extract". ② Brand reputation: Choose products produced by well-known raw material suppliers with certification and a complete quality system, such as APPCHEM. ③ Formulation and compounding: Choose capsule, liquid, or other formulations according to personal preferences.
Q: Is Silymarin and Silymarin Extract Natural?
A: Yes, the Silymarin extract produced by APPCHEM is 100% derived from natural Silymarin plant seeds, purified through physical and food-grade solvent extraction, and does not contain any artificially synthesized chemical components.
Reference
[1]Extraction of silymarin compounds from milk thistle (Silybum marianum) seed using hot, liquid water as the solvent. J. F. Alvarez Barreto et al. [2002-10-04]
[2]ALcoholic extraction of silymarin oil from seeds of the local Milk thistle plant (silybum marianum) at room temperature. Zainab Abdul Wahab Shahab et al. [2019-12-31]
[3]Role of Milk Thistle (Silybum marianum) as a Therapeutic Feed Additive in Livestock, Poultry, and Humans. Muhammad Asnan et al. [2024-06-21]
[4]Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-Chemistry, Bioavailability, and Metabolism. [2017-10-11]
[5]Separation and characterization of silybin, isosilybin, silydianin, and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry. [2006-05-26]
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