Polygonum Cuspidatum, also known as Japanese knotweed, is a perennial plant that has been used for its medicinal properties for centuries. In traditional Chinese medicine, the rhizome of Polygonum cuspidatum is widely used due to its effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, and dispelling wind and dampness. With the development of modern phytochemistry and pharmacology, Polygonum cuspidatum extract has become a highly anticipated star ingredient in the global dietary supplement and functional food market, with its core value being the abundance of various highly bioactive natural compounds.
1. What is Polygonum Cuspidatum Extract?
The efficacy of Polygonum cuspidatum extract is mainly attributed to its unique chemical composition spectrum, among which the most core and extensively studied are the stilbene compounds, especially Resveratrol and its glycoside form - Polydatin/Piceid.[3] Resveratrol is a powerful polyphenolic antioxidant, known as a key component of the "French miracle," associated with various benefits such as cardiovascular health, anti-aging, and metabolic regulation. Tiger cane is one of the most abundant plant sources of resveratrol in nature.
In addition to resveratrol and puerarin, Polygonum cuspidatum extract also contains other important active ingredients, such as anthraquinone compounds, such as Emodin, Physcion, and their corresponding glycosides, which have shown potential in anti-inflammatory and regulating intestinal health.[4]
2. What is the Process Flow Diagram?
To preserve the bioactive ingredients in Polygonum cuspidatum to the greatest extent possible and ensure the product's purity and safety, industrial production typically employs a series of optimized and standardized extraction processes. A complete production process typically includes key steps such as raw material pretreatment, multi-stage extraction, purification, concentration, and drying.
The process of making Polygonum Cuspidatum Extract is generally divided into the following steps:
1. Raw material preparation: Select high-quality Polygonum Cuspidatum plants, wash them, and cut them into small pieces.
2. Extraction: Preliminarily wash small pieces of Polygonum Cuspidatum with water to remove impurities. Then use organic solvents such as ethanol and n-propanol to carry out further extraction. Beneficial components will be further extracted under conditions such as heating and stirring.
3. Filtration: Filter the extracted liquid to remove residues and impurities to obtain a liquid with higher purity.
4. Hydrolysis: The extracted liquid is hydrolyzed to hydrolyze high molecular compounds, such as polysaccharides, into low molecular compounds to facilitate body absorption.
5. Concentration: Concentrate the synthetic liquid after filtration and hydrolysis. The purpose of this step is to evaporate the water in the liquid and improve the content and purity of the product.
6. Drying: Dry the concentrated liquid to make it into powder, which is convenient for storage and sale.
3. Is Polygonum Cuspidatum Extract Effective? How Does It Work?
Numerous preclinical studies, including cell experiments and animal models, have confirmed the potential benefits of Polygonum cuspidatum extract and its core components in multiple health fields. The complex molecular mechanisms behind these effects are achieved by regulating key signaling pathways in the body.
3.1 Powerful antioxidant and anti-inflammatory activity
Efficacy verification: The extract of Polygonum cuspidatum showed significant free radical scavenging ability and antioxidant activity. In animal models, it can effectively alleviate tissue damage caused by oxidative stress and inflammatory reactions.
For example, research has shown that Polygonum cuspidatum extract can alleviate asthma symptoms, and its mechanism is closely related to anti-inflammatory effects.
3.2 Regulating uric acid metabolism and maintaining joint health
Efficacy verification: Hyperuricemia is the main cause of gout. Multiple animal experiments have consistently shown that Polygonum cuspidatum extract has a significant uric acid-lowering effect.
The extract of Polygonum cuspidatum has been proven to reduce serum uric acid levels in hyperuricemia model rats and mice by inhibiting the activity of xanthine oxidase (XOD).[1,2]
3.3 Cardiovascular Health
Polygonum Cuspidatum Extract has been shown to have a positive effect on cardiovascular health. It helps reduce cholesterol levels, lower blood pressure, and prevent the formation of blood clots. These effects help to improve blood flow and reduce the risk of heart disease and stroke. By promoting cardiovascular health, merchants can attract customers who are looking for natural ways to improve their heart health.
4. Wide Application Areas and Product Forms
With its clear health benefits and solid scientific endorsement, Polygonum cuspidatum extract has become an important ingredient in the fields of dietary supplements, functional foods, and cosmetics.
- Application fields:
4.1 Dietary supplements: mainly used to support joint health (lowering uric acid, anti-inflammatory), anti-aging and cellular health (antioxidant), cardiovascular health support, and metabolic health management.
4.2 Functional foods and beverages: can be added to functional beverages, nutrition bars, solid drinks, and other products to give extra health value to ordinary foods.
4.3 Cosmetics: Due to its antioxidant and anti-inflammatory properties, Polygonum cuspidatum extract is also used in skincare products to help resist environmental stress and delay skin aging.[68-80-155] CIR (Cosmetic Ingredient Committee) evaluated its safety for use in cosmetics in its final report released in 2023.[6]
Common product forms: Currently, the mainstream product forms on the market include capsules, tablets, powders (which can be directly consumed or added to food), and liquid extracts.[6]
5. Certificates
Security statement：
Our company guarantees that the goods sent are safe, non-flammable, and non-explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company.
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Reference
[1]Advances in the treatment of hyperuricemia with traditional Chinese medicine. Gong Fang et al.[2024-05-31]
[2]Research Progress on the Uric Acid-Lowering Effects of Polygonum cuspidatum. Ji J et al. [2025-08-25]
[3]Solvent Fractionation of Polygonum cuspidatum Sieb. et Zucc. for Antioxidant, Biological Activity, and Chromatographic Characterization. Yuchen Cheng et al. [2025-07-21]
[4]Five bioactive compounds in Polygonum cuspidatum were determined by HPLC [2014-03-20]
[5]Anti-inflammatory Effects of Polygonum cuspidatum Hot Water Extract in Lipopolysaccharide-stimulated RAW 264.7 Cells and λ-Carrageenan-induced Paw Edema Mouse Model. Jong Hui Kim et al. [2024]
[6]Safety Assessment of POLYGONUM CUSPIDATUM EXTRACT as Used in Cosmetics. Li Jincong. et al. [2023-01-01]
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