Diosmin Powder

Diosmin Powder is a naturally occurring flavonoid compound primarily extracted from the peel of citrus plants such as the sweet orange (Citrus sinensis) and refined through standardised processes. It finds extensive application in pharmaceuticals and dietary supplements. As a plant-derived active ingredient with clearly defined functional properties, Diosmin Powder has become a key raw material in vascular health products due to its therapeutic value in improving venous function and microcirculation. Leveraging mature extraction and refinement technologies,

APPCHEM maintains stringent control over the purity, stability, and batch consistency of Diosmin Powder. This commitment aims to provide pharmaceutical companies and dietary supplement manufacturers with functional ingredients of assured efficacy and controlled quality. Research and practical application demonstrate that Diosmin Powder ​​​​​​is frequently employed to support venous tone, enhance blood return, and improve microcirculatory function. It holds particular significance in formulations addressing chronic venous insufficiency and leg heaviness.

Diosmin Powder is typically supplied in powder form, facilitating its incorporation into pharmaceutical preparations, compound tablets, capsules, and functional dietary supplements. With growing consumer focus on vascular health, health management for sedentary populations, and health concerns among middle-aged and elderly individuals, demand for Diosmin in pharmaceutical and nutritional health markets continues to rise, demonstrating stable and long-term market potential.

XI'AN APP-CHEM BIO (TECH) CO., LTD. (APPCHEM) provides Diosmin Powder utilising a mature, reproducible industrial plant extraction process, comprising the following principal steps:

1. Washing
2. Filtering
3. Removing impurities
4. Drying: to prevent high-temperature damage to thermosensitive active ingredients, especially volatile oils.
5. Crushing: (such as 80 mesh) to increase the contact area with the solvent and improve extraction efficiency.
6. Extraction
7. Solid-liquid separation
8. Purification
9. Concentrate
10. Drying
11. Smashing
12. Packaging
13. Finished product

The core value of Diosmin Powder lies in its extensively clinically validated, multifaceted efficacy targeting the venous system and microcirculation. Its mechanism of action is complex and synergistic, primarily encompassing enhanced venous tone, promotion of lymphatic drainage, anti-inflammatory and antioxidant effects, and capillary protection.

• Enhancing Venous Tone and Blood Return (Venotonic Action)

Diosmin Powder significantly strengthens venous wall tone, reducing venous distensibility and capacity to counteract venous stasis. Its molecular mechanism lies in prolonging and amplifying the vasoconstrictive effect of noradrenaline (NE) on venous smooth muscle. Additionally, it increases vascular smooth muscle sensitivity to calcium ions, maintaining venous contractility even under adverse acidosis conditions. Through these actions, diosmin effectively promotes venous blood return to the heart, reduces venous hypertension, and fundamentally alleviates the pathological basis of chronic venous insufficiency.

• Enhancing Lymphatic Drainage and Reducing Oedema (Lymphodynamic Effects)

Diosmin Powder exhibits a distinct activating effect on the lymphatic system. It increases the number of functional lymphatic capillaries while enhancing the frequency and intensity of lymphatic vessel contractions. This significantly improves lymphatic drainage efficiency, accelerating the clearance of excess proteins and fluids from interstitial tissues. Clinical studies demonstrate that Diosmin Powder effectively reduces leg swelling, with efficacy surpassing that of non-micronised flavonoid preparations.

• Anti-inflammatory and Antioxidant Effects (Cellular Protection)

Diosmin Powder exhibits potent anti-inflammatory and antioxidant activity. It effectively inhibits the synthesis of key inflammatory mediators such as prostaglandin E2 (PGE2) and thromboxane A2 (TXA2). Concurrently, it inhibits leukocyte activation, migration, and adhesion to vascular endothelium, reducing levels of pro-inflammatory factors including tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Regarding antioxidant effects, diosmin directly scavenges free radicals, mitigating oxidative stress damage to vascular endothelium. These actions collectively protect microcirculation from inflammatory and oxidative injury.

• Protection of Microcirculation and Reduction of Capillary Permeability

Diosmin Powder enhances the resistance of capillary walls, reducing abnormal permeability. This helps prevent the leakage of fluids and proteins from the bloodstream into tissues, thereby alleviating oedema and inflammatory responses. By stabilising vascular endothelial cells and improving microvascular blood flow, it provides tissues with a healthier perfusion environment.

Diosmin Powder, as a raw material, exhibits a high degree of alignment between its application domains and product positioning, primarily targeting the pharmaceutical and premium dietary supplement markets where stringent requirements exist for quality, purity, and efficacy.

• Pharmaceutical Formulations

This represents the most significant and demanding application area for Diosmin Powder. The raw material must comply with pharmaceutical-grade standards as stipulated by the European Pharmacopoeia (Ph. Eur) or the United States Pharmacopoeia (USP). Within this sector, Diosmin is typically utilised as a high-purity powder (e.g., 95%, 98% or higher) serving as an Active Pharmaceutical Ingredient (API).

Common Dosage Forms:

1. Oral Tablets/Capsules: The most prevalent form, particularly enteric-coated tablets designed to bypass gastric acid and enhance bioavailability. Notable brands such as Daflon and Detralex employ this formulation.
2. Micronised Purified Flavonoid Complex (MPFF): An advanced formulation of diosmin, typically a micronised blend of diosmin and hesperidin in a 90:10 ratio. Micronisation reduces particle size to the micrometre range (e.g., D90 < 2μm), significantly enhancing solubility and absorption.
3. Topical formulations: Such as creams and gels, used for local relief of symptoms associated with varicose veins, haemorrhoids, etc.

• Dietary Supplement Sector

As a dietary supplement ingredient, Diosmin Powder provides products with a clear vascular health positioning. It is commonly found in supplements targeting niche markets such as circulatory health, leg lightness, and haemorrhoid care.

Common product forms:

1. Vegetable capsules or tablets: Formulated as a single ingredient or combined with horse chestnut extract, aescin, citrus bioflavonoids, etc., to create synergistic formulations.
2. Powder: Can be incorporated into meal replacement powders or functional beverages, though its poor water solubility necessitates special formulation techniques such as solid dispersions.

XI'AN APP-CHEM BIO (TECH) CO., LTD. (APPCHEM)
Bon Natural Life(Nasdaq: BON)

The Company is headquartered in Xi'an High-tech Zone, Shaanxi Province, with an independent R&D centre and testing laboratories. Its Dali and Tongchuan production sites cover a total area of nearly 20,000 square meters, and it operates through the marketing networks in and out of China.

DALI FACTORY

Covering 30 acres and a building area of 11000 m²
Having a plant extract workshop, a precision drying and packaging workshop, and a spice refining workshop

TONGCHUAN FACTORY

Covering 20 acres, with a construction area of 6900 m²
Having 3 clean workshops, 2 formula product production lines, and 1 special food production line under construction

2006

Since

17,900 m²

Building area

90M

Order received

30+

atents

Security statement：

Our company guarantees that the goods sent are safe, non-flammable, and non-explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company.

Hot Tags: Diosmin Powder, manufacturers, suppliers, factory, wholesale, best, price, buy, for sale, bulk.

Long-term cooperative logistics companies include international logistics companies such as DHL, FedEx, UPS, etc.

The regular bulk packaging of the product is a 25kg plastic bag and a cardboard drum. The sample is packaged in an inner aluminium foil bag and an outer plastic bag, supporting customised packaging solutions.

XI'AN APP-CHEM BIO (TECH) CO., LTD. (APPCHEM) regularly participates in international raw material exhibitions such as CPHI, SSW, and In Cosmetics Asia, and establishes long-term cooperative relationships with global customers.

Q1. How is the purity of this product verified?
A1: We employ authoritative analytical methods such as High Performance Liquid Chromatography (HPLC) and Ultraviolet Spectroscopy (UV) to ensure a content of 90%.

Q2. What is the minimum order quantity for Diosmin Powder?
A2: Our minimum order quantity (MOQ) varies by product and specific requirements, and is typically negotiable. Please contact us for detailed information.

Q3. What is the delivery timeframe for the product?
A3: Delivery times depend on order volume and product type. Generally, we arrange production and dispatch promptly upon order confirmation.

Q4. Does APPCHEM offer customisation services?
A4: Yes, we provide customisation services including packaging, labelling, and adjusting product specifications to meet specific client requirements.

Q5. How does APPCHEM ensure product quality and stability?
A5: We maintain a rigorous quality control system. All products undergo third-party testing, with detailed Certificate of Analysis (COA) and stability data provided.

Reference
[1]R. Patil, P. Malpure et al. "Formulation, Development, and In-Vitro Evaluation of a Film-Coated Tablet Containing a Flavonoid Diosmin and Hesperidin Combination." Pharmacophore (2022).
[2]Ramona Oana Gunache (Roșca), C. Apetrei. "Determination of Diosmin in Pharmaceutical Products with Chemically Modified Voltammetric Sensors." International Journal of Molecular Sciences (2021).
[3]Sonia Pielorz, Magdalena Węglińska et al. "Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy." Molecules (2022).
[4]F. Ai, Y. Ma et al. "Preparation, Physicochemical Characterization and In-vitro Dissolution Studies of Diosmin-cyclodextrin Inclusion Complexes." Iranian Journal of Pharmaceutical Research (IJPR), 2014.
[5]M. Campanero, M. Escolar et al. "Simultaneous determination of diosmin and diosmetin in human plasma by ion trap liquid chromatography-atmospheric pressure chemical ionisation tandem mass spectrometry: Application to a clinical pharmacokinetic study." Journal of pharmaceutical and biomedical analysis (2010).