Olive Leaf Extract Oleuropein Powder Bulk Supply

Olive Leaf Extract Oleuropein Powder is a natural iridoid glycoside compound extracted and purified from the dried leaves of the olive tree (Olea europaea L.). Oleuropein is the most abundant and characteristic active component in olive leaves; it belongs to the class of iridoid glycosides, with a structure comprising a glycosidic moiety and a glucose molecule. As the core active ingredient in olive leaf extract, oleuropein possesses extensive application value.

This product is positioned for the global B2B bulk raw materials market. As a source manufacturer, we specialise in providing professional-grade raw materials, characterised by high purity (HPLC 10%–80%, customisable), batch consistency, quality control, and supply chain traceability to buyers in the plant extract industry, product R&D teams, manufacturing facilities, and brand decision-makers. We hold international certifications, including ISO 9001, ISO 22000, Kosher, and Halal, with an annual supply capacity exceeding 500 tonnes. We offer flexible sample support (minimum sample quantity of 50g) and aim to meet the end-to-end requirements of enterprise-level clients, from R&D testing to large-scale global production.

PS: This page focuses on the Integrated Supply Chain & Solutions.

For the product application information, please click Antimicrobial Ingredient Oleuropein Powder.

For the product Technical Data Sheet, please click Oleuropein Powder HPLC20% 32619-42-4.

As a high-value active ingredient in olive leaf extracts, oleuropein faces several critical bottlenecks in its transition from laboratory research to large-scale commercial application. 

Challenge 1: Technical Barriers to High-Purity, Large-Scale Production and Cost Control

The natural content of oleuropein in olive leaves is relatively limited, and its extraction and purification process involves several critical process steps:

• Process-Dependency of Extraction Efficiency: Olive leaves contain various furanocoumarin terpenoids, with oleuropein being the most abundant active component. Obtaining high-purity oleuropein from olive leaves requires precise solvent extraction and chromatographic purification techniques. Differences in processes between manufacturers directly result in significant variations in product yield, purity, and impurity profiles.
• The non-linear relationship between purity and cost: Standard specifications for oleuropein include grades of 10%, 20%, 40%, 60%, and 80%. Increasing purity from 20% to 80% involves advanced purification processes such as multi-stage chromatography and low-temperature concentration, placing higher demands on production equipment and technical expertise. The ability to consistently supply high-purity grades is a key indicator of a source manufacturer's technical capabilities.
• Thermal stability constraints on the process: Oleuropein is heat-sensitive and may degrade under high-temperature conditions. Research confirms that the stability of oleuropein is easily affected by factors such as temperature, pH, and light exposure. This necessitates the use of low-temperature processing technologies during production, placing higher demands on equipment configuration and process control.

For B2B clients, this implies that when procuring oleuropein, the maturity of the supplier's extraction process, the stability of purity specifications, and batch-to-batch quality consistency are more critical decision-making factors than price alone. There may be a fundamental difference in the performance of products from a supplier capable of providing only crude extracts compared to a source manufacturer with advanced purification capabilities during subsequent formulation development.

Our scientific response and product solutions: As a source manufacturer, we have established a comprehensive technical control system covering the entire supply chain from raw materials to finished products:

• Targeted extraction and gradient purification technology: We employ proprietary solvent extraction combined with multi-stage chromatography to efficiently concentrate oleuropein from olive leaves, and utilise a gradient crystallisation process to produce products of varying purity specifications. We have established mature production routes and stable batch control standards for various specifications, including 10%, 20%, 40%, 60%, and 80%.
• Full-process low-temperature protection: The entire process, from extraction to drying, is conducted under low-temperature control (<60°C), minimising thermal degradation losses during processing and ensuring the product's 'true purity' rather than merely its apparent purity.
• HPLC dual-standard testing system: We not only provide data on the main component content but also control the profiles of key impurities, ensuring consistent purity of the main peak and reproducible impurity profiles across HPLC chromatograms of different batches.

As a source manufacturer, we have established a comprehensive quality assurance system and the capacity for immediate supply. Core Strengths are as follows:

• Source manufacturing, controllable quality: We have specialised in the research, development and production of plant extracts for over twenty years, and operate an integrated production facility covering everything from raw material procurement to modern extraction and purification. Our annual production capacity for oleuropein exceeds 500 tonnes, enabling us to meet the diverse needs of global clients, ranging from small-scale R&D to large-scale mass production.
• Comprehensive international certifications: Our production facility strictly adheres to the ISO 9001 Quality Management System, ISO 22000 Food Safety Management System and HACCP standards, with key production processes compliant with cGMP guidelines. We also hold international certifications such as Kosher and Halal, enabling us to meet the specific requirements of different markets and religious cultures.

• Professional technical services: We are equipped with an application laboratory and a team of experienced technical consultants, capable of providing targeted application advice, specification recommendations and stability testing support to clients during the early stages of formulation development.

In the plant extract industry, the procurement of bulk raw materials typically involves a process ranging from initial evaluation to long-term partnership. For the bulk supply of Olive Leaf Extract Oleuropein Powder, the cooperation process is generally divided into several stages to ensure the product can be reliably integrated into the customer's production system.

• Enquiry and Requirements Confirmation: Clients contact us via the website contact form or directly by email/telephone, providing details of the intended application, target specifications (10%/20%/40%/60%/80% or other), sample requirements and estimated usage volume.
• Sample Provision and Technical Support: Enquiries are responded to within 24 hours, with samples and the corresponding batch Certificate of Analysis (COA) dispatched as required. For complex applications, preliminary technical consultations may be initiated to conduct component analysis and application testing on the samples, such as solubility, stability and performance within formulations. Data from the sample batch is typically used as a reference standard for future production batches to ensure consistency in long-term supply.
• Commercial Negotiations and Contract Signing: We provide competitive quotations and supply schedules based on purchase volume, packaging and logistics requirements. We accept various payment methods, including Telegraphic Transfer (T/T) and Letters of Credit (L/C).
• Production Scheduling and Rigorous Quality Control: Once an order is confirmed, stock items are dispatched within 3–5 working days; customised or bulk orders have a lead time of 2–4 weeks, with comprehensive pre-shipment quality inspections carried out.
• Mass Production and Delivery: After production is completed in accordance with the established schedule and quality inspections are passed, the products are transported to the customer's location via international logistics networks. Each batch is accompanied by test reports and relevant documentation to meet international trade requirements.

1. Industrial Packaging System

Olive leaf extract powder is susceptible to environmental factors during transport and storage; therefore, the packaging system must balance protective performance with transport efficiency.

Common packaging structures consist of inner and outer packaging. Inner packaging typically uses food-grade aluminium foil pouches or PE bags; these materials offer excellent moisture-proof and anti-oxidation properties, protecting the product's active ingredients from degradation. Outer packaging is usually cardboard drums or fibre drums, which possess strong compression resistance and are suitable for long-distance transport.

Packaging specifications:

• 1kg/bag: Aluminium foil bag (lined with a food-grade sterile bag, vacuum-sealed)
• 5kg/bag: Aluminium foil bag, housed in an external moisture-proof cardboard drum
• 25kg/drum: Cardboard drum or HDPE drum, lined with a double-layer food-grade plastic bag

Customised packaging can be provided upon request.

Storage conditions: Store in a sealed, light-protected, dry and cool place; for long-term storage, refrigeration at 4°C is recommended.

Shelf life: 24 months under correct storage conditions.

As humidity levels fluctuate significantly during sea transport, packaging is typically supplemented with desiccants or sealed structures to minimise the risk of moisture ingress. These measures effectively ensure the product's quality remains stable following prolonged transit.

2. International Logistics System Logistics Services

• Logistics Partners: We have established stable partnerships with international logistics giants such as DHL, FedEx and UPS to provide door-to-door transport services.
• Transport Methods: Sea freight and air freight. Sea freight is suitable for bulk orders; it is lower in cost but takes longer. Air freight is suitable for samples or urgent orders; it shortens delivery times but is more expensive.
• Trade Terms: common options include FOB, CIF, CFR, DAP and DDP. Different clients may select the appropriate model based on their own import capabilities; for example, large-scale traders may prefer FOB, whilst brand clients may favour the DDP model.

• Estimated Delivery Times:

1. Sample orders: 3–5 working days

2. Small-batch stock orders (<100kg): 3–7 days

3. Bulk orders by air freight: 5–8 days

4. Bulk orders by sea freight: 15–30 days (depending on destination)

• Delivery and ongoing support: Complete customs clearance documentation (commercial invoice, packing list, certificate of origin, COA, MSDS, etc.) is provided with the shipment, along with end-to-end logistics tracking. We continue to monitor customer usage post-delivery and provide necessary follow-up technical advice.

Q1: What is the relationship between oleuropein (CAS 32619-42-4) and hydroxytyrosol (CAS 10597-60-1)?

A1: Oleuropein is the primary furan-type terpenoid glycoside found in olive leaves; it can be hydrolysed in vivo or during processing to produce hydroxytyrosol. Hydroxytyrosol is the active metabolite of oleuropein and possesses stronger antioxidant activity.

Q2: What is the solubility of oleuropein? For which product systems is it suitable?

A2: Oleuropein is soluble in ethanol, propylene glycol and alkaline aqueous solutions, but has limited solubility in pure water. This characteristic makes it suitable for: 1) alcohol-based or water-alcohol mixed systems (such as tinctures and oral solutions); 2) oil-based systems, where it must be incorporated using emulsification techniques; 3) skincare products, where it can be used in conjunction with solubisers. We can provide solubility data tailored to different application scenarios.

Q3: How can the oral bioavailability of oleuropein be improved?

A3: Recent research indicates that the use of Proniosomes nanoparticle encapsulation technology can significantly enhance the stability and bioavailability of oleuropein. The liposomes formed upon hydration control the release of oleuropein in simulated gastrointestinal fluid, protecting it from degradation and enhancing delivery efficiency within intestinal cells. We recommend that clients opt for a collaborative development programme utilising advanced delivery technologies.

Q4: What is the minimum order quantity (MOQ)?

A4: The MOQ for standard products is 25 kg, and for sample orders it is 50 g. For new customers or those in the R&D phase, we encourage validation through sample testing first.

Q5: What is the product lead time?

A5: Stock orders can be dispatched within 3–7 days; for customised or bulk orders, the lead time is 2–4 weeks after the contract comes into effect. Specific lead times depend on order volume, specifications and destination.

Olive bitter glycosides are one of the core, high-value ingredients in our olive extract product range. To assist you in developing more innovative and competitive end products, we recommend that you also consider the following products that offer synergistic effects or share a common origin:

Visit our website(www.appchem.com) to view our complete catalogue of plant extracts and discover more specialised ingredient solutions.