What Is the Oleuropein Powder?
Oleuropein is a cycloartenol glycoside naturally found in Oleaceae plants and is one of the most abundant active compounds in olive leaves. As the key bioactive compound in olive polyphenols, oleuropein is renowned for its exceptional antioxidant, anti-inflammatory, hypoglycaemic, and cardioprotective properties, making it a crucial raw material for the development of functional foods, dietary supplements, and natural medicinal products.
As a by-product of the olive oil processing industry, olive leaves have long been largely discarded, resulting in a waste of resources. Recent research has shown that olive leaves are rich in high-value polyphenols such as oleuropein, and modern extraction and purification technologies can transform this waste into a valuable resource. To this end, we are launching this 20% oleuropein powder (CAS: 32619-42-4), rigorously quantified via HPLC. It is not merely a raw material, but a standardised olive polyphenol solution designed for procurement managers, product development engineers, and quality decision-makers in the plant extract industry.
PS: This page focuses on the product Technical Data Sheet.
For the product application information, please click Antimicrobial Ingredient Oleuropein Powder.
For Integrated Supply Chain & Solutions, please click Olive Leaf Extract Oleuropein Powder Bulk Supply.
What Are the Product Properties and Safety Data?
Physical and Chemical Properties
| Common Name | Oleuropein |
| Other Name | Olive leaf extract; Oleuropeine glucoside |
| CAS Number | 32619-42-4 (Unique Chemical Substance Identifier) |
| Molecular Formula |
C₂₅H₃₂O₁₃
|
| Molecular Weight | 540.51 g/mol |
| EINECS | 251-129-6 |
| Melting point | 89-90 °C(lit.) |
| Boiling point | 772.9±60.0 °C(Predicted) |
| Density | 1.50±0.1 g/cm3(Predicted) |
| Acidity constant (pKa) | 9.70±0.10(Predicted) |
| LogP | -0.865 (est) |
| InChIKey | RFWGABANNQMHMZ-JUVTZQQOSA-N |
| Specific rotation | D20 -147° (H2O, alcohol, or acetone); D20 -127° |
| Appearance and Characteristics | This product is a fine, uniform powder ranging in colour from yellowish-brown to dark brown, with a characteristic odour. |
| Solubility | Easily soluble in organic solvents such as methanol, ethanol and acetone; soluble in water. Its good solubility ensures excellent compatibility in formulations for functional foods, beverages and cosmetics. |
| Stability | Oleuropein is heat-sensitive; it is recommended to store the product in a sealed container in a cool (<25°C), dry place, protected from light. Research indicates that the use of a combination of macroporous resin and nanofiltration technology can prevent thermal effects during processing, thereby helping to preserve the thermally unstable component, oleuropein. Under these conditions, the product has a shelf life of up to 24 months. |
Safety and Compliance Criteria
This product's safety standards comprehensively reference regulatory requirements from major markets, including China, the European Union, and the United States. Both internal and third-party laboratories have validated all data.
| Heavy Metal Limits |
Complies with stringent restrictions outlined in the 2020 edition of the Chinese Pharmacopoeia: Lead (Pb) ≤ 1 mg/kg Arsenic (As) ≤ 1 mg/kg Cadmium (Cd) ≤ 1 mg/kg Mercury (Hg) ≤ 0.1 mg/kg |
| Pesticide Residues | Screening employs GC-MS/MS and LC-MS/MS methods to ensure no detection or levels below the limit of quantification for over 200 common pesticides. |
| Microbial Control |
Total Aerobic Bacteria ≤ 1,000 CFU/g Total mould and yeast count ≤ 100 CFU/g Not detectable: Escherichia coli, Salmonella spp., Staphylococcus aureus |
| Non-GMO and Non-Irradiated Declaration | The raw materials for this product are sourced from non-genetically modified olive resources. No genetically modified techniques or irradiation sterilisation have been used at any stage of the production and processing process, and a written declaration to this effect is provided. The product complies with Kosher and Halal certification requirements. |
TDS Guide
As the key active ingredient in olive leaves, the concentration of oleuropein directly influences its potency and range of applications. A professional Technical Data Sheet (TDS) not only specifies the HPLC concentration but also explains the scientific rationale behind the different specifications.
Standard specification: HPLC 20% oleuropein. This is a common industrial specification in the dietary supplement and functional food sectors, striking a good balance between bioactivity, application costs and formulation compatibility.
| Specification | Typical Content | Cost Implications | Efficacy & Application Differences |
| Standard Grade | 1% - 15% | Economical | Suitable for cost-sensitive foundational products with broad efficacy targeting; formulation loading capacity must be adequately reserved. |
| Standard Grade | 20% - 60% | Optimal cost-effectiveness | Active ingredients are clearly defined, with precise calculation of addition levels. Suitable for sectors demanding strict purity, safety, and sensory quality standards, including food and beverages, health supplements, and pharmaceuticals. |
| High-purity Grade | 70% - 95% | Higher cost | Suitable for high-end formulations or research applications with specific requirements regarding active ingredient concentration. |
Key Considerations: Selecting products of different specifications primarily involves balancing cost, application areas, and regulatory requirements. Regardless of the specification you choose, you will receive our consistent assurance of reliability in raw material sourcing, safety testing, and quality control systems.
What Does the Certificate of Analysis (COA) Include?
We undertake to provide a Certificate of Analysis (COA) compliant with international standards with every batch of products. The development and validation of the testing methods for this product have been carried out in accordance with authoritative standards such as the United States Pharmacopoeia (USP), the European Pharmacopoeia (EP) and the Chinese Pharmacopoeia (CP), to ensure global compliance of the data. Furthermore, every test result on the COA can be traced back to the original records and is available for audit and verification by clients or third parties.
Note: The COA information provided on this page is for illustrative purposes only and is intended to demonstrate our quality control parameters and capabilities. Oleuropein is heat-sensitive; therefore, samples must be handled in the dark and at low temperatures. For the specific COA document for the actual product (including the exact batch number, HPLC test data and chromatograms), please refer to the final version issued by our sales representative.
How Do the Advanced Extraction and Purification Processes Work?
We utilise a proprietary, environmentally friendly production process to efficiently extract and purify high-concentration oleuropein from olive leaves, a by-product of olive processing. The diagram below illustrates the key stages of the process, from raw material to finished product.
Further information: The flowchart above illustrates the main stages of the process. For more detailed production information, including specific process parameters, patent details and production capacity, please contact our sales representatives. We will be happy to provide further technical consultation tailored to your specific requirements.
How Does the End-to-End Quality Management Ecosystem Work?
The quality management system we have established is a closed-loop ecosystem covering the entire lifecycle from cultivation and production through to testing and release, centred on the principles of 'prevention first, full process control, and data traceability'.
Source Control (Upstream)
- Geographical Advantages: Olive trees are widely cultivated in regions such as Gansu, Sichuan and Yunnan in China, and research institutions such as the Lanzhou Institute of Chemistry, Chinese Academy of Sciences, have long been conducting research into the high-value utilisation of olive leaf resources.
- Utilisation of By-products: We primarily utilise leaf by-products from the olive processing industry as feedstock, which aligns with the principles of a circular economy and sustainable development, thereby realising a resource recycling model of 'resource – product – by-product – remanufacturing'.
- Dual Verification of Incoming Raw Materials: Each batch of raw materials must be accompanied by a certificate of origin. Upon arrival at the factory, the materials first undergo rapid QC testing (moisture content and TLC screening). If they pass, they are transferred to the holding warehouse, where they undergo comprehensive screening for pesticide residues and heavy metals to ensure that only high-quality raw materials are used in production.
Production Process Control (Midstream)
- HACCP-based Critical Control Point Management: Multiple Critical Control Points (CCPs) are established along the entire production line. For example, online monitoring is conducted during the extraction (CCP1), resin purification (CCP2), nanofiltration concentration (CCP3) and drying (CCP4) processes to ensure that operations remain within the pre-validated 'design space'.
- Clear Batch Management: Strict adherence to clean-out procedures, material identification and electronic batch record systems is enforced to eliminate any potential mix-ups or cross-contamination.
Laboratory Quality Assurance (Downstream)
- Release Testing and Stability Studies: Every batch of finished product must pass comprehensive testing covering all physicochemical and safety parameters. We possess advanced analytical equipment, including HPLC, UV, GC-MS and ICP-MS, to analyse multiple quality parameters such as oleuropein content, related substances, moisture, heavy metals and microbiological counts.
- Stability Studies: Long-term and accelerated stability tests are conducted in accordance with the company's internal control standards and guidelines to scientifically determine the shelf life. As oleuropein is heat-sensitive, the impact of temperature conditions must be taken into account in stability studies.
What Certifications and Supporting Documentation Are Available?
Our commitment to transparency in quality and our R&D capabilities are underpinned by the following authoritative certifications, patented technologies and supporting documentation. System Certification Certificates:
- ISO 22000 Food Safety Management System Certification
- ISO 9001:2015 Quality Management System Certification
- Kosher & Halal Certification
- FDA-registered facility
- ...
Obtaining Original Documents and In-Depth Audits: We fully recognise the importance of reviewing original documents during the supplier selection process. Should you require original or certified copies of the above certificates, patent documentation, or supporting documents for specific batches for formal supplier evaluation or reference purposes, please get in touch with your dedicated account manager. We will fully cooperate to provide the necessary materials to support your decision-making process.
What Product Benefits and Custom Formulation Support Are Available?
Efficacy Applications and Customised Formulation Support Based on well-defined molecular mechanisms and extensive pharmacological research data, oleuropein is an ideal raw material for developing multi-target efficacy products. Overview of Core Efficacy Applications:
- Potent antioxidant activity
- Anti-inflammatory effects
- Cardiovascular protection
- Hypoglycaemic effects
- Joint protection
- Organ protection
Recommended Formulation Combinations:
- Joint Health Formula: Oleuropein + Rutin + Curcumin.
- Antimicrobial Care Formula: Oleuropein + Chlorhexidine Gluconate.
- Cardiovascular Health Formula: Oleuropein + Coenzyme Q10 + Red Yeast Rice Extract.
- Blood Sugar Management Formula: Oleuropein + Chromium/Cinnamon Extract/Mulberry Leaf Extract.
- Antioxidant and Anti-ageing Formula: Oleuropein + Resveratrol/Grape Seed Extract/Vitamin C.
Customised Solutions: We have a dedicated application R&D team that can provide customised technical support-ranging from raw material formulation recommendations and stability studies to sample production-based on your specific product concepts (such as compound formulations for joint health, functional foods for blood sugar management, and antioxidant oral solutions).
Contact Us: Should you require a Certificate of Analysis (COA), Technical Data Sheet (TDS), MSDS, HPLC test data, samples, or wish to discuss customisation requirements for a specific batch, please do not hesitate to contact our technical sales team. We provide free samples for testing; don't hesitate to get in touch with us to arrange delivery before placing an order.
Reference
1. Bourquelot, E., & Vintilesco, J. (1908). On oleuropein, a new glucoside from olive leaves with bitter taste. Journal de Pharmacie et de Chimie.
2. Zhang, W. (2015). Effects of oleuropein on learning and memory abilities inAlzheimer's disease mouse models. Chinese Journal of Gerontology, 35(14), 16541658
3. Zhang, W. (2022). Protective effects of oleuropein on amyloid plaque deposition, neuroinflammation, and memory impairment in APP/PS1 transgenic mice. Chinese Pharmacological Bulletin.
4. Hu, G., et al. (2019). Affinity between oleuropein and AB1-42 and its protective effect on AB1-42-induced Neuro-2a cell apoptosis. Chinese Pharmacology Bulletin,35(1),107-112.
5. De Stefani, D., et al. (2024). Mitochondrial calcium uptake declines during ageing and is directly activated by oleuropein to boost energy metabolism. Cell Metabolism,36(12),1-15.
6. Kilic, A., et al. (2025). From in silico design to in vitro validation: Surfactant-free synthesis of oleuropein-loaded levan nanoparticles. Carbohydrate Polymers, 310,121773.
7. Market Research Intellect. (2024). Global oleuropein market analysis 2023-2031. Industry Report.
