Products Description
Dihydromyricetin (DMY) is a natural flavonoid compound with the chemical formula C₁₅H₁₂O₈. It is mainly found in the young stems and leaves of Ampelopsis Grossedentata, a plant in the grape family, with a content of over 30% of dry weight.[4] Its molecular structure contains 5 phenolic hydroxyl groups, endowing it with strong antioxidant properties. As a dietary supplement, DMY is applied in the form of a high-purity extract, which has the characteristics of good water solubility and high bioavailability.
Core positioning: Natural liver protection, hangover relief, blood glucose regulation, and antioxidant functional ingredients, suitable for people with alcohol metabolism disorders, liver injury risk, and auxiliary management of chronic metabolic diseases.
Molecular formula: C15H12O8
Molecular weight: 320.25
EINECS No.: 200-001-8
Structural formula:
2. Certificate of Analysis(COA)
| Item | Specification | Result | Method |
| Purity | 98.0% | 98.3% | HPLC |
| Appearance | Light Yellow Powder | Conforms | Organoleptic |
| Odor &Taste | Characteristic | Conforms | Organoleptic |
| Physical&Chemical Characteristics | |||
| Loss on Drying | <5.0% | 1.3% | GB 5009.3 |
| Ash | ≤1.0% | 0.7% | GB 5009.4 |
| Heavy metals | |||
| Lead(Pb) | ≤1.0ppm | Conforms | GB 5009.12 |
| Arsenic(As) | ≤1.0ppm | Conforms | GB 5009.11 |
| Mercury(Hg) | ≤0.5ppm | Conforms | GB 5009.17 |
| Cadmium(Cd) | ≤1.0ppm | Conforms | GB 5009.15 |
| MicrobiologicalTests | |||
| Total plate Count | <1000cfiu/g | Conforms | GB 4789.2 |
| Yeast & Mold | ≤100cfwg | Conforms | GB 4789.15 |
| Coliforms | ≤10cfu/g | Conforms | GB 4789.3 |
| Salmonella | Negative | Negative | GB 4789.4 |
| Staphylococcus | Negative | Negative | GB 4789.10 |
| Conclusion: | Conforms to specification | ||
3. Product efficacy and mechanism of action
3.1 Antioxidant effect
Mechanism: Clears superoxide radicals (O ₂⁻), hydroxyl radicals (· OH), and lipid peroxidation radicals (ROO ·), and inhibits lipid peroxidation.[1]
Data: The DPPH radical scavenging rate IC ₅₀=4.2 μ g/mL is superior to vitamin C (IC ₅₀=5.8 μ g/mL) [107]. Quantum chemistry calculations confirm
that its phenolic hydroxyl group neutralizes free radicals through hydrogen transfer.[1]
3.2 Liver protection and sobering effect
Mechanism: Activate the Nrf2 pathway, increase reduced glutathione (GSH) levels, and reduce malondialdehyde (MDA) content. Inhibit hepatic steatosis induced by ethanol metabolite acetaldehyde.
Data: The mouse model (50mg/kg DMY) showed a 40% reduction in liver injury and a 35% decrease in MDA.[2] Preclinical studies have shown that sobering up time is reduced by 50%.
3.3 Hypoglycemic effect
Mechanism: Inhibits alpha-glucosidase activity (IC₅₀=18.7 μg/mL) and delays glucose absorption. Regulating the PI3K/Akt pathway to enhance insulin sensitivity.[3]
Data: The blood glucose of alloxan diabetes mice decreased by 28.3% (200mg/kg DMY, 4 weeks).
4. Application Fields and Product Forms
| Field | Product form | Dosage | Case |
| Dietary supplement | tablets, capsules (500mg/capsule) | 200-300mg/day | Liver protection and hangover relief tablets, blood glucose balance capsules |
| Functional food | solid beverage, meal replacement stick | 0.5% -2% | DMY fortified meal replacement powder |
| Cosmetic | antioxidant essence, facial mask | 1% -3% | Liver spot repair essence |
| Animal nutrition | feed additive (aquatic/poultry) | 100-200mg/kg | anti-stress feed |
5. Certificates
Security statement：
Our company guarantees that the goods sent are safe, non-flammable, and non-explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company.
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Reference
[1] Research progress on detection, pharmacological effects, and pharmacokinetics of dihydromyricetin, Luo Jun et al. [2020-01-01]
[2] Research on the Biological Efficacy of Dihydromyricetin Xu Jingjuan et al.
[3] Mechanism study of dihydromyricetin alleviating LPS-induced oxidative stress damage in chicken liver through miR-138-5p/SIRT1 Zhang Yuanyuan [2022-06]
[4] He Guixia, Pei Gang, Zhou Tianda, etc Determination of Total Flavonoids and Dihydromyricetin Content in Xianchi Snake Grape [J]. Chinese Journal of Traditional Chinese Medicine, 2000. [2000-07-25]
[5] Density functional theory study on the molecular structure and properties of dihydromyricetin Xin Guopeng et al. [2025-02]
