98% Artemisinin Powder

98% Artemisinin Powder is a high-purity, standardised botanical active ingredient designed for the global pharmaceutical and premium dietary supplement markets. This product is a white crystalline powder refined from the dried aerial parts of the Asteraceae plant Artemisia annua L. through advanced extraction, separation, and purification processes. As a sesquiterpene lactone compound, artemisinin is renowned for its unique endoperoxide bridge structure, which is central to its potent biological activity. (The 98% purity specification indicates that, as determined by authoritative analytical methods such as High Performance Liquid Chromatography (HPLC), the content of artemisinin (Molecular Formula: C₁₅H₂₂O₅) in this raw material is no less than 98%.)

Market Positioning:

98% Artemisinin Powder is precisely positioned for two high-growth sectors demanding exceptional raw material quality.

• Pharmaceutical Sector:

98% Artemisinin Powder serves as the critical starting material or active pharmaceutical ingredient (API) for artemisinin-based combination therapies (ACTs) recommended by the World Health Organisation (WHO). Leveraging its high purity and stringent impurity control, 98% artemisinin powder serves as a premium pharmaceutical intermediate for synthesising bioavailable, stable artemisinin derivatives such as artesunate, artemether, and dihydroartemisinin.

• Dietary Supplement Sector:

Artemisinin's potential in immune support, anti-inflammatory effects, cellular health, and antioxidant properties is extensively researched and recognised. Positioned as a high-value functional ingredient, 98% artemisinin powder is utilised in developing capsules, tablets, and other products focused on enhancing immune system function, promoting healthy ageing, and maintaining cellular homeostasis. Our high-purity 98% Artemisinin Powder ensures that end-use supplement products deliver precise, effective dosages, meeting consumer demand for high-quality, scientifically substantiated health products.

XI'AN APP-CHEM BIO (TECH) CO., LTD. (APPCHEM) provides 98% Artemisinin Powder utilising a mature, reproducible industrial plant extraction process, comprising the following principal steps:

1. Washing
2. Filtering
3. Removing impurities
4. Drying: to prevent high-temperature damage to thermosensitive active ingredients, especially volatile oils.
5. Crushing: (such as 80 mesh) to increase the contact area with the solvent and improve extraction efficiency.
6. Extraction
7. Solid-liquid separation
8. Purification
9. Concentrate
10. Drying
11. Smashing
12. Packaging
13. Finished product

The value of 98% artemisinin powder lies in its potent and diverse biological activity. Research into its mechanism of action not only elucidates the source of its efficacy as an antimalarial drug but also opens up broad prospects for its application in the field of dietary supplements.

• Highly Effective Antimalarial

Artemisinin and its derivatives form the cornerstone of global malaria control, particularly against Plasmodium falciparum – the species exhibiting resistance to traditional drugs such as chloroquine. Artemisinin's antimalarial mechanism is widely recognised as arising from the activation of its unique intramolecular peroxy bridge structure by ferrous ions (Fe²⁺) within the parasite. Upon entering infected erythrocytes, the peroxy bridge undergoes a Fenton-like reduction-cleavage reaction with the parasite's ferrous ions. This cleavage generates a cascade of highly reactive oxygen species (ROS) and carbon-centred radicals. Multi-target assault: These radicals act as "molecular bombs", inflicting non-specific alkylation and oxidative damage upon biomolecules within the parasite. This multi-target "saturation attack" pattern renders it difficult for the parasite to develop resistance through single-gene mutations. This explains artemisinin-based drugs' high efficacy, rapid action, and relatively slow emergence of resistance.

• Anti-inflammatory Effects

98% artemisinin powder exhibits significant anti-inflammatory and immunomodulatory activity. Artemisinin exerts effects by inhibiting multiple pro-inflammatory signalling pathways. By suppressing NF-κB, artemisinin reduces inflammatory mediator production at its source. Additionally, it may influence other pathways such as the MAPK pathway, collectively contributing to its broad anti-inflammatory effects.

• Anti-tumour Effects

Research into artemisinin's anti-tumour properties represents one of the most active fields of study. Extensive in vitro and in vivo investigations have confirmed its inhibitory effects on multiple cancer cell lines. Mirroring its anti-malarial mechanism, artemisinin's anti-tumour activity is highly dependent on iron ions. Rapidly proliferating cancer cells exhibit upregulation of surface transferrin receptors, leading to significantly higher intracellular iron concentrations than in normal cells. This provides a target for artemisinin's selective cytotoxic action. 

• Drug Intermediates and APIs:

As a high-purity starting material, 98% artemisinin Powder serves as an indispensable core ingredient for synthesising a range of semi-synthetic artemisinin derivatives (such as artemether and dihydroartemisinin). These derivatives exhibit superior stability, solubility, and pharmacokinetic properties compared to artemisinin itself, forming the core components of ACTs-the global standard for antimalarial treatment. Our supplied raw materials strictly adhere to pharmaceutical-grade quality control standards, ensuring optimal yields in downstream synthesis reactions and the purity of the final API.

• Premium Dietary Supplements:

Within the nutritional health sector, 98% artemisinin powder is utilised in developing various premium dietary supplements, primarily in hard capsule and tablet formulations.

The product is mainly in the form of standardised plant extract powder and supports customisation of content, making it easy for OEM/ODM customers to design formulas.

Security statement：

Our company guarantees that the goods sent are safe, non-flammable, and non-explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company.

Hot Tags: Artemisinin, manufacturers, suppliers, factory, wholesale, best, price, buy, for sale, bulk.

Long-term cooperative logistics companies include international logistics companies such as DHL, FedEx, UPS, etc.

The regular bulk packaging of the product is a 25kg plastic bag and a cardboard drum. The sample is packaged in an inner aluminium foil bag and an outer plastic bag, supporting customised packaging solutions.

XI'AN APP-CHEM BIO (TECH) CO., LTD. (APPCHEM) regularly participates in international raw material exhibitions such as CPHI, SSW, and In Cosmetics Asia, and establishes long-term cooperative relationships with global customers.

Q1: Do you offer customisation options for different specifications?

A: We accommodate bespoke requirements (such as high purity exceeding 99% or specific solvent residue control). Particle fineness (80-200 mesh available) and packaging specifications (ranging from kilogram to tonne quantities) can be adjusted according to client formulations and dosage form development needs.

Q2: How is quality, stability and traceability ensured throughout the artemisinin production process?

A: We implement comprehensive quality control across the entire supply chain:

• Raw material traceability: Artemisia annua sourced from our own GACP (Good Agricultural Collection Practice) certified farms, with batches traceable to specific cultivation plots.
• Production Process: Combining low-temperature extraction with chromatography technology minimises degradation of heat-sensitive components. Each batch undergoes HPLC, GC, heavy metal, and microbiological testing.
• Certification Support: We provide COA (Certificate of Analysis), GMP certification, and accelerated stability testing data.

Q3: Can technical data supporting the synergistic application of artemisinin with other ingredients be provided?

A: We offer our collaborative partners an exclusive technical support package, including: In vitro synergistic experimental data for artemisinin with curcumin, piperine and other compounds; solubility and stability references across varying pH environments; formulation development recommendations for anti-malarial and immunomodulatory applications. Sample technical white papers may be requested via our business email address.

Reference

[1]Didik Harmoko, V. Prasasty et al. "Mechanism Analysis of Artemisinin and Artesunate as Lung Cancer Therapy Agents Through in Silico Method." Online Journal of Biological Sciences (2024).
[2]P. O'Neill, Victoria E. Barton et al. "The Molecular Mechanism of Action of Artemisinin-The Debate Continues." Molecules (2010).
[3]J. Kindermans, J. Pilloy et al. "Ensuring sustained ACT production and reliable artemisinin supply." Malaria Journal (2007).
[4]R. Ruswanto, Richa Mardianingrum et al. "Reverse Docking, Molecular Docking, Absorption, Distribution, and Toxicity Prediction of Artemisinin as an Anti-diabetic Candidate." (2020).