What is Phloretin Powder?
Phloretin Powder is a plant polyphenol of dihydrochalcone, which can be extracted from apple and grapefruit peel, and can protect plants from ultraviolet rays. For human skin, phloretin has strong antioxidant and photoprotective effects (can eliminate UV-induced increase in skin free radicals and damage to cells and DNA) and can inhibit matrix metalloproteinases (MMP-1). ) and elastase, enzymes that degrade the skin's connective tissue and play an important role in skin photoaging. The phloretin powder is extracted from the peel and root bark of juicy fruits such as apples and pears and is a kind of dihydrochalcone.
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Solubility: Soluble in hot water and ethanol, insoluble in ether and benzene |
| Melting point: 260ºC |
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Molecular formula: C15H14O5 |
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Molecular weight: 274.27 |
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EINECS/ELINCS Registration Number:200-488-7 |
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Structural formula: |
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Certificate Of Analysis (COA)
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Product Name |
Phloretin |
Botanical Source |
Malus pumila Mill. |
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CAS No. |
60-82-2 |
Plant Part |
Branch |
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ITEM |
SPECIFICATION |
RESULT |
TEST METHOD |
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Physical Description |
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Appearance |
Off White Powder |
Conforms |
Visual |
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Odor |
Characteristic |
Conforms |
Organoleptic |
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Taste |
Characteristic |
Conforms |
Olfactory |
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Particle size |
95% passes through an 80 mesh sieve |
Conforms |
CP2020 |
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Chemical Tests |
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Assay |
≥98.0% |
98.53% |
HPLC |
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Loss on drying |
≤1.0% |
0.38% |
CP2020 |
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Ash |
≤1.0 % |
0.10% |
CP2020 |
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Heavy Metals |
≤10 ppm |
Conforms |
CP2020 |
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Lead (Pb) |
≤2ppm |
Conforms |
CP2020(AAS) |
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Arsenic (As) |
≤1ppm |
Conforms |
CP2020(AAS) |
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Cadmium (Cd) |
≤2 ppm |
Conforms |
CP2020(AAS) |
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Mercury (Hg) |
≤1ppm |
Conforms |
CP2020(AAS) |
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Microbiology Control |
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Aerobic bacterial count |
≤1,000 cfu/g |
Conforms |
CP2020 |
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Total Yeast & Mold |
≤100 cfu/g |
Conforms |
CP2020 |
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Escherichia coli. |
Negative |
Conforms |
CP2020 |
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Salmonella |
Negative |
Conforms |
CP2020 |
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Conclusion |
Conforms to specification |
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Storage: |
Store in tightly sealed and preferably full containers in a cool, dry, and ventilated area. |
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Shelf Life |
24 months when properly stored. |
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Status: |
Non-irradiation; Non-GMO; No Carrier; Halal & Kosher certified. |
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Is Apple Extract Phloretin Effective?
Apple Extract Phloretin
Regulating blood sugar
Phloretin has shown significant potential in regulating blood glucose homeostasis. It is a well-known inhibitor of sodium glucose cotransporters (SGLT1 and SGLT2). SGLT1 is mainly distributed in the small intestine and is responsible for absorbing glucose from food; SGLT2 is mainly located in the kidneys and is responsible for reabsorbing filtered glucose back into the bloodstream.
Regulating lipid metabolism
Oral Phloretin can significantly reduce fat accumulation in the liver. On the one hand, Phloretin can downregulate the expression of key transcription factors related to fat synthesis, thereby inhibiting endogenous fat synthesis in the liver; On the other hand, it can activate the Sirt1/AMPK signaling pathway, promote the oxidative breakdown of fatty acids, and inhibit fat production.
Broad-spectrum antioxidant
Phloretin, as a polyphenolic compound, has strong antioxidant capacity. The multiple phenolic hydroxyl groups in its molecular structure can directly scavenge various free radicals (such as superoxide anions and hydroxyl radicals), blocking the chain reaction of oxidative damage. In addition, Phloretin can also exert antioxidant effects indirectly.
What Are the Applications of Apple Extract Phloretin?
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Cosmetic ▲Inhibit the effect of tyrosinase, lighten the spots, and whiten the skin; ▲ Strong antioxidant capacity can effectively delay skin wrinkles, aging, and other aging symptoms ▲ It can prevent sugar components from entering epidermal cells ▲ Strong moisturizing effect. |
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Health products ▲ Anti-oxidation and anti-free radical effects; ▲Anti-inflammatory and immunosuppressive effects. |
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Flavors, Spices ▲Inhibit bitterness and other unpleasant tastes in food and improve taste. ▲ Reduce the odor of high-intensity sweeteners and cover up bad flavors; ▲Use stevia as a taste regulator. |
Certificates
Security statement：
Our company guarantees that the goods sent are safe, non-flammable, and non-explosive, and consistent with the declaration. Under normal transportation conditions, all losses caused by the products sent by our company shall be borne by our company.
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Reference
[1]J. Ehrenkranz, N. Lewis et al. "Phlorizin: a review." Diabetes/Metabolism Research and Reviews (2005). [2005]
[2]Phloretin: A Dihydrochalcone with Many Interesting Biological Properties. [2024-07-16]
[3]Kai Xü, Haitao Lü et al. "High-speed counter-current chromatography preparative separation and purification of phloretin from apple tree bark." Separation and Purification Technology (2010). [2010-05-11]
[4]Effects of dietary supplementation of organic acids and phytase on performance and intestinal histomorphology of broilers. [2016-01-01]
[5]Talita Pizza Anunciato Casarini, L. Frank et al. "Dermatological applications of the flavonoid phloretin." European journal of pharmacology (2020. [2020-09-21]
