Polygoni Multiflori Preparata Extract

Polygoni Multiflori Preparata Extract is a natural active ingredient concentrate derived from the traditional Chinese medicine Polygonum multiflorum Thunb. root, processed through a specific processing technique of "nine steaming and nine sun drying" or similar methods.

Polygonum multiflora, also known as Polygonum multiflora and wisteria, is a perennial entwining vine of the Polygonaceae, with thick roots and dark brown. Polygonum multiflorum contains anthraquinone compounds, mainly chrysophanol, emodin, rhein, chrysophanol anthrone, and stilbene compounds.
Polygonum multiflorum is a common Chinese herbal medicine widely used in the development of medicines, health products, and daily chemical products. The stilbene is a unique water-soluble bioactive ingredient in Polygonum multiflorum; it is also an effective cosmetic and skincare ingredient. Therefore, Polygoni multiflori preparata extract is widely used as a cosmetic additive either orally or externally.

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The excellent quality of Polygonum Multiflorum Extract comes from a rigorous, standardized, and technologically advanced production process. This process aims to maximize the retention and enrichment of key active ingredients while effectively removing potential useless or harmful substances, ensuring the safety, effectiveness, and batch consistency of the final product.

• Fresh fruits are washed
• Filter
• Remove impurities
• Drying: to prevent high-temperature damage to thermosensitive active ingredients, especially volatile oils.
• Crushing: (such as 80 mesh) to increase the contact area with the solvent and improve extraction efficiency.
• Core extraction
• Solid-liquid separation
• Purification
• Concentrate
• Drying
• Smash
• Packaging
• Finished product

The application value of Polygonum multiflorum extract in the field of dietary supplements is rooted in its diverse biological activities and solid scientific research foundation. Its efficacy is not limited to a single target, but rather, through complex network regulatory mechanisms, it generates overall health benefits for the human body system.

Polygonum multiflorum extract, especially its iconic component THSG, has shown great potential in delaying aging.
The THSG molecular structure contains multiple phenolic hydroxyl groups, giving it a strong ability to directly scavenge free radicals. THSG can upregulate the nuclear factor E2-related factor 2 (Nrf2) signaling pathway.

With the increasing social pressure and aging population, maintaining cognitive health has become an important consumer demand. Polygonum multiflorum extract has shown unique application prospects in this field.
The active ingredients in Polygonum multiflorum extract can inhibit excessive activation of microglia and reduce the release of inflammatory factors such as tumor necrosis factor-α (TNF-α) and interleukin-1 β (IL-1 β).

Polygonum multiflorum extract has a positive effect on regulating blood lipids and blood sugar. It can activate peroxisome proliferator-activated receptor alpha (PPAR alpha), which increases glucose uptake and utilization in skeletal muscle and adipose tissue by activating the AMPK signaling pathway, thereby playing an auxiliary role in regulating blood sugar.

In summary, the efficacy of extracting Polygonum multiflorum is not just empty talk, but is based on a series of rigorous modern scientific research. It synergistically exerts key health benefits such as anti-aging, nerve protection, and metabolic regulation through multi-target and multi-pathway approaches, making it a functional raw material with great scientific value and application potential in the dietary supplement market.

• Healthy aging and anti-aging products:

Dietary supplements can be developed for middle-aged and elderly populations, which can be combined with anti-aging ingredients such as coenzyme Q10, PQQ (pyrroloquinoline quinone), and resveratrol to form a synergistic anti-aging solution.

• Brain Health and Cognitive Support Products:

Targeting students, mental health workers, and middle-aged and elderly individuals with cognitive health needs. The product can be combined with brain-boosting ingredients such as phosphatidylserine (PS), DHA, and Ginkgo biloba extract to develop a comprehensive brain nutritional supplement.

• Nutricosmetics:

Oral beauty products can be developed, emphasizing "shining hair from the inside out", "nourishing hair follicles", "anti-oxidation, brightening skin tone". This field can be compounded with classic beauty ingredients such as collagen peptides, Biotin, and sodium hyaluronate.

• Metabolic Health and Weight Management Products:

Targeting individuals at risk of metabolic syndrome, products can be positioned as "maintaining healthy cholesterol levels", "assisting with blood glucose management", etc. Combined with ingredients such as berberine, chromium, bitter gourd extract, etc., it can provide more comprehensive metabolic support.

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Reference

[1]Traditional usages, botany, phytochemistry, pharmacology, and toxicology of Polygonum multiflorum Thunb.: A review. Longfei Lin et al. [2015]

[2]Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action. Wenping Tang et al. [2020-05-09]

[3]Inhibitory effects of Polygonum multiflorum extract and its constituents on UGT1A1. Xu. [2017-12-20]

[4]Metabolomics Analysis of Region-Specific Polygoni Multiflori Radix Metabolite Profiles. Yonghui Rui et al. [2022-11-23]