Apple Extract Procyanidin B2 HPLC Test 29106-49-8

Procyanidin B2 is a naturally occurring B-type procyanidin dimer found in young apples (Malus pumila Mill.) and grape seeds. As the most representative active component among oligomeric proanthocyanidins (OPCs), Procyanidin B2 exhibits the most pronounced antioxidant activity among its eight isomers.

Many commercially available "grape seed extracts" or "apple polyphenols" products merely declare total polyphenol content, failing to guarantee the stable presence and precise quantification of proanthocyanidin B2, a critical monomer. This poses challenges for B2 clients in efficacy validation, formulation accuracy, and quality consistency.

To address this, we introduce this high-purity procyanidin B2 powder (CAS: 29106-49-8), rigorously quantified via HPLC. It represents not merely a raw material but a monomeric active-ingredient solution tailored for procurement managers, product development engineers, and quality decision-makers within the botanical extract industry. Strictly adhering to international pharmacopoeia standards and ISO quality management systems, this product delivers core value through: clearly defined monomers, precise HPLC quantification, and full traceability throughout production. We are committed to providing a comprehensive product dossier that presents a complete quality evidence chain from molecular structure to factory-release reports, thereby establishing ourselves as a reliable link in your supply chain.

PS: This page focuses on the product Technical Data Sheet.

For product application information, please click Antioxidant Ingredient Procyanidin B2 Powder.

For Integrated Supply Chain & Solutions, please click Apple Extract Procyanidin B2 Powder In Stock.

Safety and Compliance Criteria

This product's safety standards comprehensively reference regulatory requirements from major markets, including China, the European Union, and the United States. Both internal and third-party laboratories have validated all data.

Proanthocyanidin B2, as a monomeric active ingredient, exhibits efficacy intensity and application scenarios directly influenced by its purity. A professional Technical Data Sheet (TDS) not only defines HPLC purity but also elucidates the commercial and scientific rationale behind different specifications.

Standard Specification: HPLC ≥ 6% Proanthocyanidin B2. This represents the industry-standard high-purity monomeric specification, suitable for targeted efficacy research and premium formulation development.

Key Considerations: Selecting products of different specifications primarily involves balancing cost, potency and formulation positioning. Regardless of the specification you choose, you will receive our consistent assurance of reliability in raw material sourcing, safety testing and quality control systems.

We undertake to provide a Certificate of Analysis (COA) compliant with international standards with every consignment. The development and validation of our testing methodologies incorporate authoritative standards such as the United States Pharmacopoeia, European Pharmacopoeia, and Chinese Pharmacopoeia to ensure global data compliance. Furthermore, every test result on the COA is traceable to its original records and supports audit verification by clients or third parties.

Important Notice: The COA information provided on this page is for illustrative purposes only, intended to demonstrate our quality control dimensions and capabilities. For the specific COA documentation of actual products, please refer to the final version issued by our business specialists.

We employ our proprietary green preparation process to efficiently extract and purify high-purity procyanidin B2 from young apple fruits. The diagram below illustrates the key process steps from raw material to finished product.

Further Information: The flowchart above outlines the primary stages of the process. For more detailed production information regarding specific process parameters, capacity details, and customised production, please contact our business specialists. We shall provide further technical consultation tailored to your specific requirements.

The quality management system we have established constitutes a closed-loop ecosystem that encompasses the entire lifecycle, from cultivation and production through testing to release. Its core principles are "prevention-oriented, fully controllable throughout, and data traceable".

Source Control (Upstream)

Geographical Advantage: Based in Shaanxi, China – one of the world's largest apple-producing regions – with abundant, high-quality raw apple fruit resources.

Standardised Raw Material Management: Collaborating with audited contract farms, conducting annual baseline testing of soil and irrigation water to ensure consistent raw material quality.

Dual Verification of Raw Material Entry: Each batch must be accompanied by a certificate of origin. Upon arrival, materials undergo preliminary QC rapid testing. Upon arrival at the factory, materials undergo preliminary QC screening (moisture content, TLC rapid screening). Only those passing this stage are admitted to the holding area for subsequent comprehensive screening for pesticide residues and heavy metals, ensuring only premium-quality raw materials enter production.

Production Process Control (Midstream)

HACCP-Based Critical Point Management: Multiple Critical Control Points (CCPs) are established throughout the production line. For instance, online monitoring during purification (CCP1) and drying (CCP2) ensures processes operate within pre-validated "design space".

Batch Traceability Management: Rigorous implementation of area clearance, material identification, and electronic batch record systems eliminates any potential for confusion or cross-contamination.

Laboratory Quality Assurance (Downstream)

Release Testing and Stability Studies: Each batch of finished product must undergo comprehensive testing covering all physicochemical and safety parameters. Equipped with advanced analytical instruments including HPLC, UV and GC, we assess multiple quality indicators such as proanthocyanidin B2 content, related substances, loss on drying, heavy metals and microbial levels.

Digital Traceability and Continuous Improvement

End-to-End Electronic Traceability System: The MES system enables bidirectional electronic traceability from customer orders through to sales dispatch.

Third-Party Authoritative Validation: Finished products are periodically submitted to international third-party institutions such as SGS and Eurofins for parallel testing, serving as independent validation of the internal quality control system.

Our transparent quality commitment and R&D capabilities are underpinned by the following authoritative certifications, patented technologies, and supporting documentation.

System Certification Certificates:

• ISO 22000 Food Safety System Certification
• ISO 9001 Quality Management System Certification

Key Supporting Documentation:

• FDA, KOSHER, HALAL, SC...
• Full-project Quality Inspection Reports (batch-specific)
• Material Safety Data Sheet (MSDS)
• Factory Audit Report Summary

We fully recognise the importance of reviewing original documentation during supplier selection. Should you require access to originals or certified copies of the aforementioned certificates, patent documentation, or batch-specific supporting files for formal supplier evaluation or reference purposes, please contact our dedicated manager. We shall provide full cooperation in supplying the required materials to support your decision-making process.

Based on its well-defined molecular mechanisms, high-purity proanthocyanidin B2 serves as an ideal raw material for developing multi-targeted functional products.

• Core Functional Applications:
• Cardiovascular Protection
• Antioxidant Stress
• Oral Care and Periodontal Health
• Skin Whitening

Recommended Combination Formulations:

• Cardiovascular Health Protocol: Proanthocyanidin B2 + Coenzyme Q10 + Red Yeast Rice Extract. Multi-pathway synergy targets oxidative stress, endothelial function, and lipid metabolism for comprehensive cardiovascular support.
• Oral Care Protocol: Proanthocyanidin B2 + Xylitol + Green Tea Extract. For toothpaste, mouthwash, and dental powders, provide natural anti-inflammatory and anti-periodontitis solutions.
• Brightening & Anti-Ageing Solution: Proanthocyanidin B2 + Vitamin C + Hyaluronic Acid. Establishes a multi-faceted skincare system combining antioxidant defence, melanin inhibition, and hydrating repair.
• Hair Regrowth & Nourishment Solution: Proanthocyanidin B2 + Biotin + Caffeine. For scalp serums, anti-hair loss shampoos and similar products, targeting follicular health.

Reference

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[2]SIDDALL J K, SHETTY S D, COOPEREH.Measurements ofserumgamma-seminoproteinandprostate specific antigen were evaluated for monitoringcarcinoma of the prostate[J]. Clinical Chemistry, 1986,32(11):2040-2043.
[3]VAN DEN BROECK T. VAN DENBERGH R C N,BRIERS E, et al. Biochemical recurrence in prostatecancer: the European Association of Urology prostate cancer guidelines panel recommendations[J]. European Urology Focus, 2020, 6(2): 231-234.

[4]DE LA IGLESIA R, MILAGRO FI, CAMPIONCAMPIONJ, et al. Healthy properties of proanthocyanidins [J].BioFactors, 2010, 36(3): 159-168.