What Is the Pomegranate Extract Ellagic Acid?
Ellagic acid is a naturally occurring polyphenolic compound widely distributed in various fruits and nuts, including pomegranates, strawberries, raspberries, and walnuts. It is a dimeric derivative of gallic acid and belongs to the polyphenolic lactone class of compounds. As one of the core active ingredients in pomegranate peel extracts, ellagic acid is renowned for its exceptional antioxidant properties and tyrosinase-inhibiting activity. It serves as a key raw material for developing premium skin-brightening, anti-ageing skincare products and dietary supplements.
APPCHEM presents this 98% high-purity ellagic acid powder (CAS: 476-66-4), rigorously quantified via HPLC. It represents not merely a raw material, but a comprehensive standardised solution for monomeric active ingredients, tailored for procurement managers, product development engineers, and quality decision-makers within the botanical extract industry. This product adheres strictly to international pharmacopoeia standards and ISO quality management systems, with its core value lying in: clearly defined monomers, precise HPLC quantification, and full traceability throughout the supply chain.
PS: This page focuses on the product Technical Data Sheet.
For the product application information, please click Antioxidant Ingredient Pomegranate Extract Ellagic Acid.
For Integrated Supply Chain & Solutions, please click Pomegranate Extract Ellagic Acid Original Factory.
What Are the Key Numerical Data for Ingredients?
Physical and Chemical Properties
| Common Name | Ellagic acid |
| Other Name | Dimeric derivative of gallic acid, 2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione |
| CAS Number | 476-66-4 (Unique Chemical Substance Identifier) |
| Molecular Formula |
C₁₄H₆O₈
|
| Molecular Weight | 302.19 g/mol |
| EINECS | 207-508-8 |
| Melting point | 260–265 °C |
| Boiling point | 363.24°C (rough estimate) |
| Density | 1.667 |
| Merck | 14,3547 |
| BRN | 47549 |
| LogP | 0.239 (est) |
| Appearance and Characteristics | White to off-white or pale yellow crystalline powder, free from lumps and visible foreign matter |
| Solubility | Slightly soluble in water, diethyl ether; soluble in ethanol, methanol, dimethyl sulfoxide (DMSO), dilute alkalis |
| Stability | Stable when stored at room temperature away from light; prone to oxidation and discolouration under high temperatures or strong light; recommended to store in a sealed container in a cool, dry place. |
Safety and Compliance Criteria
This product's safety standards comprehensively reference regulatory requirements from major markets, including China, the European Union, and the United States. Both internal and third-party laboratories have validated all data.
| Heavy Metal Limits |
Complies with stringent restrictions outlined in the 2020 edition of the Chinese Pharmacopoeia and the EU Cosmetics Regulation (EC) No 1223/2009: Lead (Pb) ≤ 1 mg/kg Arsenic (As) ≤ 1 mg/kg Cadmium (Cd) ≤ 0.5 mg/kg Mercury (Hg) ≤ 0.1 mg/kg |
| Pesticide Residues | Screening employs GC-MS/MS and LC-MS/MS methods to ensure no detection or levels below the limit of quantification for over 200 common pesticides. |
| Microbial Control |
Total Aerobic Bacteria ≤ 1,000 CFU/g Total mould and yeast count ≤ 100 CFU/g Not detectable: Escherichia coli, Salmonella spp., Staphylococcus aureus |
| Non-GMO and Non-Irradiated Declaration | This product's raw materials originate from non-genetically modified pomegranate sources. No genetically modified techniques or irradiation sterilisation were employed throughout the entire production and processing stages, with a written declaration provided. |
TDS Guide
Ellagic acid, as a monomeric active ingredient, exhibits efficacy intensity, application scenarios, and cost-effectiveness directly influenced by its purity. A professional Technical Data Sheet (TDS) not only defines HPLC purity but also elucidates the commercial and scientific rationale behind different specifications.
Standard specification: HPLC ≥ 98% ellagic acid. This represents the internationally recognised high-purity monomer specification for the food, pharmaceutical, and cosmetics industries, suitable for targeted efficacy research and premium formulation development.
| Specification | Typical Content | Cost Implications | Efficacy & Application Differences |
| Standard Grade | 40% - 90% | Economical | Suitable for cost-sensitive basic health products, such as common dietary supplements. Ellagic acid is one component of the pomegranate polyphenol blend. |
| High-Purity Grade | 90% - 98% | Optimal cost-effectiveness | Active ingredients are clearly defined, with precise calculation of addition levels. Suitable for efficacy-verification studies and high-end formulation development in targeted skin-brightening, antioxidant, and anti-ageing skincare applications. |
| Reference Grade | > 98% | High cost | Primarily for laboratory analytical comparison; not recommended for large-scale commercial production. |
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Key Consideration: Selecting different purity grades primarily balances cost, efficacy intensity, and formulation precision. Regardless of your specification, you receive our consistent assurance regarding raw material sourcing, safety testing, and quality control systems. 1. Consistent raw material sourcing: All sourced from non-GMO, standardised cultivation bases. 2. Consistent testing standards: Adherence to equally stringent pesticide residue and heavy metal safety testing protocols. 3. Unified quality control: Manufactured under the same ISO-certified end-to-end quality management system. |
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What Does the COA Include?
We undertake that every batch of product shall be accompanied by a Certificate of Analysis (COA) compliant with international standards. The development and validation of testing methods for this product integrate authoritative references, including the United States Pharmacopoeia, European Pharmacopoeia, and Chinese Pharmacopoeia, to ensure global data compliance. Furthermore, every test result on the COA is traceable to original records and supports audit verification by clients or third parties.
Enhanced Quality Control: Impurity Profile Analysis
Beyond quantifying primary peaks, we rigorously control related substances (relevant impurities) within the product. By establishing impurity profiles, we ensure not only that product purity meets specifications across batches, but also that impurity composition remains stable and controllable.
Important Note: The COA information provided on this page serves solely as an illustrative reference, demonstrating our quality control dimensions and capabilities. For the specific COA documentation of actual products (including precise batch numbers, HPLC test data, and spectra), please refer to the final version issued by our business specialists.
How Does the Advanced Extraction and Purification Process Work?
APPCHEM employs our proprietary green preparation process to efficiently extract and purify high-purity ellagic acid from pomegranate peel, a by-product of pomegranate processing. The diagram below illustrates the key process flow from raw material to finished product.
Further Information: The flowchart above outlines the primary stages of the process. For more detailed production information, including specific process parameters, patent particulars, and production capacity details, please contact our business specialists. We shall provide further technical discussions tailored to your specific requirements.
How Does the End-to-End Quality Management Ecosystem Work?
Our quality management system constitutes a closed-loop ecosystem spanning the entire lifecycle from cultivation and production through testing to release. Its core principles are "prevention-oriented, fully controllable, and data traceable".
Source Control (Upstream)
- Origin Traceability: Collaborate with audited contract pomegranate cultivation bases to ensure transparent sourcing and consistent raw material quality.
- Dual Verification of Incoming Raw Materials: Each batch must be accompanied by a certificate of origin. Upon arrival, materials undergo preliminary QC screening (moisture content, TLC rapid screening). Only those passing this stage enter the holding area for comprehensive pesticide residue and heavy metal screening, ensuring only premium-grade materials proceed to production.
Production Process Control (Midstream)
- HACCP-Based Critical Point Management: Multiple Critical Control Points are established throughout the production line. For instance, online monitoring is conducted during hydrolysis (CCP1), recrystallisation purification (CCP2), and drying (CCP3) processes to ensure operations remain within pre-validated "design space".
- Patented Process Assurance: Utilises proprietary patented production technology to guarantee process advancement and unique product competitiveness.
- Batch Traceability Management: Strictly implements area clearance, material identification, and electronic batch record systems to eliminate any potential confusion or cross-contamination.
Laboratory Quality Assurance (Downstream)
- Release Testing and Stability Studies: Each finished batch must pass comprehensive testing covering all physicochemical and safety parameters. We possess advanced analytical equipment, including HPLC, UV, and GC, to assess multiple quality parameters such as ellagic acid content, related substances, loss on drying, heavy metals, and microbial counts.
- Stability Testing: Conduct long-term and accelerated stability studies in accordance with internal quality control guidelines to scientifically determine shelf life. Research indicates ellagic acid maintains excellent stability after 35 days of storage at 0°C, 25°C, and 50°C.
What Certifications, Patents, and Supporting Documentation Are Available?
Our transparent commitment to quality and R&D capabilities is underpinned by the following authoritative certifications, patented technologies and supporting documentation.
Patented Technologies Showcase: Demonstrating our corporate R&D and technological innovation prowess, we hold multiple patented technologies in the field of ellagic acid production:
What Efficacy Applications and Custom Formulation Support Are Available?
Based on well-defined molecular mechanisms, high-purity ellagic acid serves as an ideal raw material for developing multi-target efficacy products.
Core Efficacy Applications Overview:
- Skin Brightening and Spot Reduction
- Antioxidant and Anti-Ageing
- Anti-Inflammatory Effects
- Hydration and Skin Barrier Repair
- Enzyme Inhibitory Activity
Recommended Combination Formulations:
- Brightening and Spot Reduction: Ellagic Acid + Arbutin/Kojic Acid/Vitamin C.
- Antioxidant and Anti-Ageing: Ellagic Acid + Grape Seed Extract/Green Tea Extract/Resveratrol.
- Hydration & Repair Formula: Ellagic Acid + Hyaluronic Acid/Ceramides/Glycerin.
- Anti-Inflammatory & Soothing Formula: Ellagic Acid + Liquorice Extract/Chamomile Extract/Centella Asiatica Extract.
Customised Solutions
Our dedicated application R&D team provides tailored technical support for your specific product concepts (e.g., specialised brightening serums for melasma, post-sun repair gels, or oral beauty beverages). This encompasses ingredient formulation recommendations, dosage form research, stability testing, and sample production.
Contact Us: For specific batch COAs, TDS, HPLC testing data, samples, or to discuss bespoke requirements, please contact our technical sales team at any time. Complimentary samples for testing are available; please enquire before placing orders.
Reference
[1]LI F P, LUO J X, XIE Q Z, et al. Differential effects of ellagic acid on non-alcoholic fatty liver disease in mice: grouped by urolithin A-producing capacity[J]. Food & Function, 2025, 16: 3166-3179. DOI: 10.1039/d5fo00440c.
[]FU H J, LI W X, CHENG Q M, et al. Ellagic acid alleviates iron overload-induced liver damage by mitigating ferroptosis through modulation of the TGFβ/Smad signalling pathway[J]. Food Research International, 2025, 214: 116590. DOI: 10.1016/j.foodres.2025.116590.
[3]NAIDU P, DAS M, HANSDA S, et al. Mechanisms of Ellagic Acid (EA)-Mediated Osteogenic Differentiation of Human Dental Pulp-Derived Stem Cells[J]. ACS Omega, 2025, 10(15): 15229-15242. DOI: 10.1021/acsomega.4c10642.
[4]XIE Z K, CHEN F, LI P, et al. Tracking the gastrointestinal fate and prebiotic effect of ellagic acid-rich fruit byproducts: a comprehensive evaluation[J]. Food Chemistry, 2025, 484: 144290. DOI:10.1016/j.foodchem.2025.144290.
