Sweetener NHDC 96 Neohesperidin Dihydrochalcone

As a dietary supplement, NHDC's value lies not only in its sweet taste, but also in its various biological activities and health benefits. Recent studies have revealed its multifaceted efficacy and mechanism of action.

4.1 Relieve Food Allergy Effect
NHDC is superior to neohesperidin in improving allergic symptoms, particularly in restoring the balance of T helper 1 and T helper 2 cells and inhibiting spleen NOTCH/nuclear factor kappa B (NF-κB) activation by enhancing binding to Hes1.

4.2 Antioxidant and anti-inflammatory effects
NHDC has significant antioxidant activity, which can effectively eliminate free radicals and alleviate cellular damage caused by oxidative stress. As a flavonoid derivative, the phenolic hydroxyl group in its molecular structure is a key functional group that exerts antioxidant capacity.

Meanwhile, research has confirmed that NHDC has significant anti-inflammatory effects, which can inhibit the production and release of inflammatory factors and alleviate inflammatory reactions. This combination of antioxidant and anti-inflammatory effects makes NHDC potentially valuable in preventing chronic diseases.

4.3 Liver Protection Function
The research on the liver protection of NHDC has shown positive results. Zhang Shuo et al. investigated the effect of NHDC on CCL4 induced liver fibrosis in mice, and the results showed that NHDC could reduce the levels of ALT/AST in the serum and hydroxyproline in the liver tissue of model mice. Other studies have shown that flavonoids such as chalcones can inhibit collagen synthesis in HSC-T6 cells in vitro and can be used as raw materials for hepatoprotective agents.

4.4 Lowering Blood Lipids and Cholesterol
NHDC exhibits lipid-lowering and cholesterol lowering effects, which helps maintain cardiovascular health. Its mechanism of action in regulating blood lipid metabolism may be related to the regulation of related enzyme activity and receptor expression. This effect makes NHDC have potential applications in preventing metabolic syndrome and related cardiovascular and cerebrovascular diseases, especially suitable for developing dietary supplements for middle-aged and elderly populations.

NHDC, with its unique performance, has demonstrated application potential in multiple fields, especially in the dietary supplement industry, where its product forms are diverse and innovative.

5.1 Dietary supplements and functional foods
In the field of dietary supplements, NHDC is mainly used as a functional sweetener and active ingredient. Specific application forms include:

• Low energy nutritional supplements
• Functional Sweet Tablets
• Metabolic health products
• Liver protection and hangover relief products

5.2 Medical Auxiliary Applications
In the field of medicine, NHDC is mainly used as a medicinal flavoring agent and bitterness masking agent. Specific applications include:

• Children's medication taste correction: Utilizing the bitterness suppressing properties of NHDC to improve the palatability of children's medication and enhance medication adherence.
• Improvement of traditional Chinese medicine preparations: Used to mask the unpleasant taste of oral Chinese medicine liquids, granules, and other dosage forms, and improve patient acceptance.
• Liver protective drug raw materials: NHDC itself can be used as a liver protective agent and stomach medicine raw material, exerting its direct pharmacological effects.

5.3 Special Foods and Beverages
In the field of food and beverage, NHDC is widely used in various foods such as fruit juice drinks, dairy drinks, fruit wine, desserts, baked goods, candies, chewing gum, seasoning sauces, etc.
 

NHDC, as a high magnification natural sweetener and functional ingredient, has a broad market prospect, especially with significant growth potential in the context of increasing health awareness.

6.1 Market Size and Growth
According to QYResearch research, the global NHDC market size is expected to reach approximately $137 million in 2024 and $216 million in 2031, with a compound annual growth rate (CAGR) of 6.8% from 2025 to 2031. This growth trend is mainly driven by the following factors: increasing global demand for low sugar and low calorie foods, expansion of the functional dietary supplement market, preference for natural source ingredients, and consumers' pursuit of "clean label" products.

6.2 Regional Market Analysis
From a regional distribution perspective, North America and Europe are currently the main consumer markets for NHDC, which is related to their developed health food industry and strict sugar intake restriction policies.

However, the Asia Pacific region is expected to become the fastest-growing market, driven by accelerated urbanization in emerging economies such as China and India, increased disposable income, and rising health awareness.

6.3 Future Development Trends
The future development of NHDC in the field of dietary supplements presents multiple clear trends:

• Driven by technological innovation: Continuous optimization of extraction processes, such as instantaneous high-pressure extraction and the application of new catalysts, is expected to further improve yield and purity, and reduce costs.
• Expansion of application areas: From traditional food and beverage to functional dietary supplements, specialty foods, personalized nutrition, and other fields.
• Innovation in ingredient combinations: Scientific research on the ratio of NHDC to other functional ingredients (such as prebiotics, phytochemicals, etc.) will lead to more innovative products.
• Deepening clinical research: With the deepening of research on the biological activity mechanism of NHDC, more evidence supporting functional claims will enhance product competitiveness.