Patent Ingredient Punicalagin HPLC40% 65995-63-3

Punicalagin is the most abundant ellagitannin compound in pomegranate (Punica granatum L.) peel and constitutes the core bioactive component of pomegranate peel polyphenols. It exists as a mixture of two isomers, α-punicalagin and β-punicalagin, exhibiting exceptional antioxidant activity and diverse biological functions.

Many commercially available "pomegranate peel extracts" merely declare total polyphenol content, lacking precise qualitative and quantitative control over punicalagin, the key monomer. This results in significant batch-to-batch quality variation and ambiguous efficacy claims, posing substantial challenges for B2B clients regarding formulation consistency, efficacy validation, and international compliance.

To address this, we introduce our HPLC 40% punicalagin powder (CAS: 65995-63-3), prepared using patented technology. This is not merely a raw material but a standardised tannin solution for procurement managers, product development engineers, and quality decision-makers within the plant extract industry. Strictly adhering to international pharmacopoeia standards and ISO quality management systems, this product delivers core value through patented process assurance, HPLC-precise quantification, stable isomer ratios, and full traceability throughout production.

PS: This page focuses on the product Technical Data Sheet.

For the product application information, please click Whitening Cosmetics Ingredient Pomegranate Extract Punicalagin.

For Integrated Supply Chain & Solutions, please click Pomegranate Extract Punicalagin In Stock.

Physical and Chemical Properties

Safety and Compliance Criteria

This product's safety standards comprehensively reference regulatory requirements from major markets, including China, the European Union, and the United States. Both internal and third-party laboratories have validated all data.

As the core active component of pomegranate peel, the purity of Punicalagin directly influences efficacy potency, application scenarios and cost-effectiveness. A professional TDS not only defines HPLC purity but also clarifies the commercial and scientific rationale behind different specifications.

Standard Specification: HPLC 40% Punicalagin. This represents a common industrial-grade extract specification, achieving a favourable equilibrium between efficacy potency, application cost, and formulation compatibility.

We undertake to provide an internationally compliant COA with every consignment. The development and validation of our testing methods for this product incorporate authoritative standards such as the United States Pharmacopoeia, European Pharmacopoeia, and Chinese Pharmacopoeia to ensure global data compliance. Furthermore, every test result on the COA is traceable to its original records and supports audit verification by clients or third parties.

Important Note: The COA information provided herein serves solely as an illustrative reference, demonstrating our quality control dimensions and capabilities. Punicalagin is photosensitive; sample handling must be conducted in light-protected conditions. The definitive COA documentation for actual products (including precise batch numbers, HPLC test data, and chromatograms) shall be as issued by our business representatives.

We employ proprietary purification technology to produce high-purity Punicalagin products. The diagram below illustrates the key process flow from raw material to finished product.

Patented Technology Description: This method enables the full utilisation of waste liquid from pomegranate peel, total phenolic extraction and anthocyanin production as raw material for synthesising high-purity ellagic acid. It plays a positive role in maximising the utilisation of natural product resources, enhancing the added value of agricultural products, alleviating environmental protection pressures, and reducing industrial production costs.

Further Information: The flowchart above illustrates the primary stages of the process. For more detailed production information, including specific process parameters, patent particulars, and production capacity specifics, please contact our business specialists. We shall provide further technical discussions tailored to your specific requirements.

Our quality management system constitutes a closed-loop ecosystem spanning the entire lifecycle from cultivation and production through testing to release. Its core principles are "prevention-oriented, fully controllable throughout, and data traceable".

Source Control (Upstream)

• Geographical Advantage: Pomegranates are extensively cultivated across China, with premium production centres in Lintong, Shaanxi and Hotan, Xinjiang. Research institutions such as the Zhengzhou Fruit Research Institute of the Chinese Academy of Agricultural Sciences conduct long-term studies on pomegranate germplasm resources and functional components.
• By-product Utilisation: The primary raw material is pomace by-product from pomegranate juice processing, aligning with circular economy and sustainable development principles.
• Dual Verification of Incoming Materials: Each batch of raw materials must be accompanied by a certificate of origin. Upon arrival at the factory, materials undergo preliminary QC rapid testing (moisture content, TLC screening). Only materials passing this initial check are admitted to the holding warehouse for subsequent comprehensive screening for pesticide residues, heavy metals, and HPLC fingerprint profiling. This ensures only premium-quality raw materials enter production.

Production Process Control (Midstream)

• HACCP-Based Critical Point Management: Multiple Critical Control Points (CCPs) are established throughout the production line. For instance, online monitoring is implemented during extraction (CCP1), resin adsorption (CCP2), and drying (CCP3) processes to ensure operations remain within pre-validated "design space" parameters.
• Patented Process Assurance: Utilisation of proprietary patented production technology guarantees process advancement and unique product competitiveness.
• Batch Traceability Management: Strict implementation of area clearance protocols, material identification systems, and electronic batch record systems eliminates any potential for confusion or cross-contamination.

Laboratory Quality Assurance (Downstream)

• Release Testing and Stability Studies: Each finished batch undergoes comprehensive testing covering all physicochemical and safety parameters. We possess advanced analytical instruments, including HPLC, UV, GC, and ICP-MS, to assess multiple quality parameters such as pomegranate Punicalagin content, isomer ratio, moisture, heavy metals, and microbial levels.
• Stability Testing: Conduct long-term and accelerated stability studies in accordance with Corporate Internal Control Standards guidelines to scientifically determine shelf life. Given pomegranate Punicalagin's photosensitivity, stability studies must account for the impact of light exposure conditions.

Our transparent quality commitment and R&D capabilities are underpinned by the following authoritative certifications, patented technologies, and supporting documentation.

System Certification Certificates:

• ISO 22000 Food Safety System Certification
• ISO 9001 Quality Management System Certification

Key Supporting Documentation:

• FDA, KOSHER, HALAL, SC...
• Full-project Quality Inspection Reports (batch-specific)
• Material Safety Data Sheet (MSDS)
• Factory Audit Report Summary

We fully recognise the importance of reviewing original documentation during supplier selection. Should you require access to originals or certified copies of the aforementioned certificates, patent documentation, or batch-specific supporting files for formal supplier evaluation or reference purposes, please contact our dedicated manager. We shall provide full cooperation in supplying the required materials to support your decision-making process.

Based on extensive scientific research data and well-defined molecular mechanisms, Pomegranate Proanthocyanidins serve as an ideal raw material for developing multi-target efficacy products.

Core Efficacy Applications Overview:

• Potent Antioxidant and Free Radical Scavenging
• Cardiovascular Protection
• Natural Antimicrobial and Preservation Properties
• Protein Oxidation Inhibition and Gel Performance Enhancement
• Anti-Inflammatory and Immune Modulation

Recommended Formulation Schemes:

• Natural Preservation Scheme: Anthocyanins + Chitosan/Tea Polyphenols.
• Cardiovascular Health Scheme: Anthocyanins + Coenzyme Q10/Resveratrol.
• Meat Product Quality Enhancement Scheme: Anthocyanins + Sodium Pyrophosphate.
• Antioxidant and Anti-Ageing Solution: Pomegranate Anthocyanins + Vitamin C/Green Tea Extract.

Customised Solutions:

Our dedicated application R&D team provides tailored technical support-from formulation recommendations and stability studies to sample production-for your specific product concepts (e.g., natural preservatives for strawberries, cardiovascular health functional foods, premium meat product enhancements).

Contact Us: For specific batch COAs, TDS, HPLC testing data, samples, or to discuss custom requirements, please contact our technical sales team at any time. Complimentary samples for testing are available; please enquire before placing orders.

Reference

[1]Fan Yongqiang, and Gulihaixia, and Zilailai Ainiwar, and Yang Qifan, and Wang Yu, and He Zongsheng, and Tian Lin'ai, and Zhang Zhizhi. "Anshiliu glycoside ameliorates abnormal autophagy and insulin signalling in the pancreas of type 1 diabetic mice." Chinese Journal of Clinical Pharmacology, 18(2020):2810-2813.

[2]Xu Ping, Yang Chengwu, Huang Shuyun, Guo Hongmin, Liu Yanping, Hong Zongyuan, Zhong Shuzhi et al. Experimental study on the cognitive function improvement of APP/PS1 Alzheimer's disease mice by anthelmintic glycoside through modulating gut microbiota [J]. Chinese Journal of Clinical Pharmacology, 2022(18):2181-2186.

[3]LIU H H, YAN C H, TEN Y, et al. Gut microbiota and D-ribose mediate the anti-colitic effect of punicalagin in DSS-treated mice[J]. Food & Function, 2024. DOI:10.1039/d4fo00741g.

[4]HAN Q Q, REN Q D, GUO X, et al. Punicalagin attenuates hyperuricemia via restoring hyperuricemia-induced renal and intestinal dysfunctions[J]. Journal of Advanced Research, 2024. DOI:10.1016/j.jare.2024.03.029.